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Evidence for similarities between cyclodiene type insecticides and picrotoxinin in their action mechanisms

, : Evidence for similarities between cyclodiene type insecticides and picrotoxinin in their action mechanisms. Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes 18(1): 1-14

Cyclodiene-type insecticides, e.g., heptachlor epoxide and .gamma.-BHC, mimicked the action of picrotoxinin. These insecticides inhibited the GABA-stimulated chloride uptake in the coxal muscle of the American cockroach, and directly competed against [3H].alpha.-dihydropicrotoxinin for binding in rat brain synaptosomes. Several cyclodiene-resistant insect strains were also resistant to picrotoxinin. This cross-resistance was specific to picrotoxinin and did not extend to other neuroexcitants. These insecticides, like picrotoxinin, caused central nerve excitation by stimulating transmitter release. Similarity in molecular structures was also pointed out. Some of the nerve excitation symptoms that insecticides caused were due to their interaction with picrotoxinin receptor.


PMID: 6187794

DOI: 10.1080/10934528309375088

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