geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Experimental investigation on various administration methods of gentamicin. Comparison of the effect of gentamicin on phagocytosis


, : Experimental investigation on various administration methods of gentamicin. Comparison of the effect of gentamicin on phagocytosis. Japanese Journal of Antibiotics 36(3): 547-551

We compared the efficacy of intravenously, intramuscularly administered or intravenously infused over 45 minutes gentamicin (GM) by the experimental system in rabbits using diffusion chambers. Serum concentrations of GM obtained with 3 administration methods were different, while the peak values after intramuscular injection and intravenous drip infusion were similar. Similar concentration time curves of GM in the chambers were revealed after intramuscular injection and intravenous infusion. No marked difference in 3 administration methods was showed in the effects on the growth of P. aeruginosa in the chamber. Viable bacterial number in the chambers decreased when the GM concentration in the chamber was 4--5 times of MIC, and thereafter regrowth was observed after the decrease of GM concentration in the chambers to 2--3 times of MIC. About 8 hours were required for growth to the base line value. In the leucocyte containing chambers, viable bacterial number similarly decreased, but the rate of regrowth was slow. About 12 hours were required for growth to the base line value. The regrowth rate in the GM containing chamber was similar to that in the antibiotic free chamber. From this result, it is suggested that, when the antibiotic concentration in the chamber is 1--2 times of MIC, antibiotic does not show the growth suppressive effect and the activating effect on phagocytosis of leucocytes in the environment closed to the practical pathological condition such as this model. For the patients with qualitative or quantitative abnormal changes of phagocyte, short interval of drug administration might be needed. For this purpose, intravenous drip infusion under monitoring of serum concentration is more suitable than intramuscular injection, which might be accompanied with severe pain and contracture of injected muscle.

US$29.90

PMID: 6410099


Other references

Cao, M.; Zachary, D.; Harry, P.; Hoffmann, JA.; Duuc, B., 1983: Purification of a 20-hydroxyecdysone binding protein from haemolymph of the locust Locusta migratoria. The blood of L. migratoria contains a carrier protein which specifically binds 20-hydroxyecdysone and which has been isolated with a high degree of purity in this study by a combination of anion-exchange chromatography, gel permeation chromatograp...

Harrison, Re, 1982: Seed supply, quality and costs--a users viewpoint Tropical pasture. Tropical grasslands 16(2): 87-88

Zamora,F.; Rodriguez,N.; Torres,D.; Yendis,H., 2008: Use of wastewater for irrigation and its effect on chemical properties of soils in the plains of Coro, Falcon State, Venezuela. With the purpose of determining the potential use of waste waters as alternative for irrigation in the semi-arid areas of Falcon State, Venezuela, its effect on chemical properties of soils was evaluated in three production zones located in the Co...

Balu, S.; Alagesaboopathi, C.; Madhavan, S., 1999: Botanical remedies for diabetes from the Cauvery Delta of Tamilnadu. The present paper deals with 30 folklore botanical remedies for diabetes in the Cauvery Delta of Tamilnadu. The methods of preparation and doses of administration of plant medicines as suggested by the herbalists are recorded in the study. Also, t...

Milstien S., 1987: Tetrahydrobiopterin other physiological roles in addition to aromatic amino acid hydroxylation?. Curtius, H -C , N Blau And R A Levine (Ed ) Unconjugated Pterins And Related Biogenic Amines; First International Workshop, Flims, Switzerland, February 28-March 7, Xiv+397p Walter De Gruyter And Co : Berlin, West Germany; New York, New York, Usa Illus 49-66

Satake, I.; Yang, J.T., 1973: Effect of chain length and concentration of anionic surfactants on the conformational transitions of poly(L-ornithine) and poly(L-lysine) in aqueous solution. Biochemical and Biophysical Research Communications 54(3): 930-936

Jordi, C.Rbe, A., 2008: Deep-sea bodotriidae (Crustacea : Cumacea) from New Caledonia, Fiji and Indonesia. Cumaceans (Crustacea: Peracarida) belonging to the family Bodotriidae collected between 206 and 3680 m depth, during the French campaigns BIOCAL and BIOGEOCAL in waters of New Caledonia, KARUBAR in Indonesia and BORDAU 1 around Fiji were studied....

Tjandrawinata, R.R.; Nofiarny, D.; Susanto, L.W.; Hendri, P.; Clarissa, A., 2011: Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea with DLBS1442, a bioactive extract of Phaleria macrocarpa. DLBS1442, a proprietary and standardized semipolar bioactive extract of the fruit Phaleria macrocarpa, is preclinically proven to have anti-inflammatory properties. The current clinical study evaluated the efficacy and safety of DLBS1442 in allevi...

Mehlsen J.; Boesen F., 1987: Substantial effect of acute hydration on blood pressure in patients with autonomic failure. The effect of acute hydration on arterial blood pressure levels was investigated in ten patients with severe postural hypotension due to autonomic failure. Blood pressure and heart rate were determined in the supine and 60-degree head-up tilted po...

Kemp, D., J.; Alcock, J., 2008: Aerial contests, sexual selection and flight morphology in solitary pompilid wasps. Aerial contest competition has proven to be a challenging phenomenon to interpret in many territorial insects. Because the duels often consist of elaborate and/or high speed ascending maneuvers, the hypothesis that they are settled due to asymmetr...