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Hematologic effects of intravesicular thiotepa therapy for bladder carcinoma


, : Hematologic effects of intravesicular thiotepa therapy for bladder carcinoma. JAMA 244(18): 2065-2067

Twenty-nine patients with bladder carcinoma treated with intravesical thiotepa administration were reviewed to assess hematologic toxicity. Ten of 25 consecutive patients had at least one episode of acute myelosuppression. Thrombocytopenia was the most common abnormality; anemia was uncommon. Acute suppression occurred most often within the first three months of therapy and was dose related. One of the 25 patients and four additional patients had chronic myelosuppression; all were male. They were older and had received more thiotepa over a longer period than those patients without chronic myelosuppression. Thrombocytopenia was again the most common abnormality. Anemia was nearly as frequent in this subpopulation and may herald chronic blood dyscrasia. One patient had refractory anemia with an excess of blast forms; another had smoldering leukemia. Acute and chronic forms of myelosuppression were not related. Thiotepa treatments should be limited to 90 mg/mo and protracted therapy avoided in elderly men.

US$29.90

PMID: 6776297


Other references

Dermer, G.B., 1967: Ultrastructural changes in the microvillous plasma membrane during lipid absorption and the form of absorbed lipid: an in vivo study. Journal of Ultrastructure Research 20(1): 51-71

Larson, R.L.; Cherin, E.C., 1981: Emergency telephone numbers of pharmaceutical companies. Hospital Pharmacy 16(10): 531-3, 537-9

Wells, J.M.; Brown, D.H., 1990: Ionic control of intracellular and extracellular cadmium uptake by the moss rhytidiadelphus squarrosus hedw. warnst. The effects of K, Ca, Mg and H ions on the kinetics of Cd uptake by the moss Rhytidiadelphus squarrosus (Hedw.) Warnst were investigated. The affinity of extracellular exchange sites for these ions decreased in the order Cd, H > Ca > Mg .mch...

Mathieu F.; Toksoz M.N.fi, 1984: Application of full waveform acoustic logging data to the estimation of reservoir permeability. Development of borehole geophysics recently focused on reservoir characterization. Within this effort, extensive full waveform acoustic surveys demonstrated a correlation between the occurrence of open fractures and attenuation of Stoneley waves....

Barankin, B.; Metelitsa, A.I.; Schloss, E.H.; Wasel, N.R., 2005: Skin disorders in Ashkenazi Jews: a review. International Journal of Dermatology 44(8): 630-635

Ruoppolo, V., 2003: Comparative pathology of cetaceans and pinnipeds. The known causes of morbidity and mortality of aquatic mammals belonging to the Order Cetacea and Suborder Pinnipedia in Brazil is limited. The aim of this work was to characterize the main processes that contribute to or cause the death of these...

Dundas-Grant, J., 1922: Case of Vertigo, due to Cholesteatoma of Attic, cured by Ossiculectomy. Proceedings of the Royal Society of Medicine 15(Otol Sect): 3-3

Bielak, F., 1980: Effect of rations with increased nitrate content on yield and chemical composition of cows' milk. This is a review of published work by the author and his collaborators in the light of other literature.

Ramadan, A.M.; El-Naggar, M.M., 1996: Synthesis, characterization and demonstration of superoxide dismutase-like activity of copper (II) chloride, bromide, nitrate, thiocyanate, sulphate, and perchlorate complexes with 2-methyl-amino pyridine. A number of copper(II) complexes containing 2-methyl amino pyridine and various anions (Cl-, Br-, NO-3-, SCN-, ClO-4-, or SO-4-2-) have been synthesized and characterized by elemental analysis, X-ray powder diffraction, IR, and electronic spectra....

Dadomo, A.; Lemmi, M.; Martinelli, G.; Menichetti, M.; Telesca, L., 2013: Springwater continuous monitoring in the LAquila area in concomitance with the April 2009 seismic swarm in central Italy; constraining factors to possible deep-seated fluid emissions. A M(L) =5.8 earthquake rocked the L'Aquila area on April 6, 2009. Several aftershocks characterized by 5<M(L) LT4 followed the main seismic event. The depth of mainshock was about 9km and the same region has been hit by strong earthquakes...