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Heterotransplants of human tumors in nude mice


, : Heterotransplants of human tumors in nude mice. Antibiotics and ChemoTherapy 28: 15-20

A short review of 10 years experience with the use of thymus-aplastic nude mice in onocology is given. All major human tumor types, e.g. lung, breast, gastrointestinal, genitourinary, malignant melanomas are now established and serially grown in nude mice. Rare human tumors with endocrine activity have also been transplanted successfully to nude mice. Transplanted tumors grow locally at the site of inoculation and metastatic spread to lymph nodes and organs is a rare event. The growth rate of the individual tumors remain constant even after several years of serial transfer. Light and electron microscopy show a close similarity of mouse grown tumors to the human donor material. As judged from isozyme studies, chromosome analyses and immunological investigations human characteristics are preserved in nude mouse grown tumors. Chemotherapy of different types of transplanted human tumors has shown that responses obtained with different tumor/drug combinations in nude mice are comparable with the results obtained by the same tumor/drug combinations in clinical practice. This model is now being employed as a secondary screening method for evaluation selected anticancer agents that are to be used in clinical trials.

US$29.90

PMID: 7416728


Other references

Zaki, S.A.; Dadge, D.; Shanbag, P.; Choudhury, R., 2010: Mature cystic teratoma: Unusual presentation as dysphagia. Indian Journal of Pediatrics 76(12): 1275-1276

Van Den Berghe H.; David G., 1979: Nonrandom chromosome anomalies in human myelo proliferative disorders. Cancer Detection & Prevention 2(1): 113-123

Zidan, Z.H.; Abdel Megeed, M.I.; Gupta, G.; Mohamed, K.A.; Weshahy, K.M.; Bayoumi, A.E., 2003: Survey and distribution of pesticides and metals in Karmout fish, Clarias lazera collected from Kalubia governorate, Egypt. The distribution of pesticides and heavy metals in different organs of the Karmout fish (Clarias lazera) collected from different markets in Kalubia Governorate, Egypt, from April 1999 to March 2000, was investigated. Significant differences in th...

Shoemaker E.M.; Roach C.H.; Byers F.M.J., 1962: Diatremes and uranium deposits in the Hopi Buttes, Arizona. The Hopi Buttes diatremes erupted in a shallow lake that was filled in as volcanic activity progressed in Pliocene time. At the end of the period of volcanism the landscape included low lava domes capping some of the diatremes, a few flows, and nu...

Kaufman, M.; Watkins, E., L., 1981: Promoting comprehensive integrated health care with emphasis on nutrition care and social work services. A pamphlet for administrators, nutritionists, and social workers from primary health care centers, local and State health departments, and central and regional offices of the US Department of Health and Human Services, summarizes issues and barrie...

Kies, C.; Lin, L.S.; Fox, H.M.; Korslund, M., 1978: Blood serum fatty acid patterns of adolescent boys as influenced by source of dietary fat corn oil butter oil safflower oil beef tallow. The influence of type of dietary fat in low fat diets fed to adolescent boys on fatty acid patterns of selected blood serum lipid fractions was investigated in 2 studies. In pre-study investigations over a 2 yr period, fat intakes of subjects were...

Sankhayan, S.D.; Shukla, U.C., 1976: Rates of urea hydrolysis in 5 soils of india. Most of the urea added to soil samples was hydrolyzed within 24 h. The rate of hydrolysis was faster at 40% of the water-holding capacity than at 60%, and was slower in soil samples with higher organic matter contents or electrical conductivity. T...

Anonymous, 2007: Outbreak news. Rift Valley fever, Sudan. Releve Epidemiologique Hebdomadaire 82(46): 401-402

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Hsieh, T-Fu.; Chang, C-Hsian.; Chang, S-San., 2006: Foreskin development before adolescence in 2149 schoolboys. We examined the external genitalia of 2149 elementary schoolboys in the suburban area of Taichung in Taiwan for an understanding of foreskin development before adolescence. The study's subjects comprised 692 first-grade boys, 725 fourth-grade...