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How far has the search for endogenous ligands of benzodiazepine receptors progressed?

, : How far has the search for endogenous ligands of benzodiazepine receptors progressed?. L'encephale 9(4 Suppl 2): 131b-142b

The discovery, in 1977, of the specific binding sites for benzodiazepines in the brain of mammals, notably in man, lends support to the possible existence of endogenous compounds acting as natural ligands of these sites. At present, a dozen of molecules having the capacity to displace bound 3H-benzodiazepines from their specific sites have been extracted from the brain of several species (rat, pig, bovine...), the cerebrospinal fluid and urine of man. These molecules are proteins, peptides, purines, beta-carbolines... and exhibit (some) pharmacological properties similar or opposite to those of benzodiazepines. The most recent data concerning benzodiazepine receptors suggest that the endogenous ligand would be, if it exists, a benzodiazepine-like compound (agonist) with an indolic structure.


PMID: 6144508

Other references

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Cates, L.Ann.; Armentrout, D., 2013: Simulation with synergy and community energy. Neonatal nurse practitioners (NNPs) have a crucial role in the management and care of critically ill newborns and infants in the neonatal intensive care unit. Their role responsibilities range from daily management of care, oversight of unit and b...

Diamandopoulos, A.A.; Goudas, P.C., 2005: The late Greco-Roman and Byzantine contribution towards the evolution of laboratory examinations of bodily excrement. Part 2: sputum, vomit, blood, sweat, autopsies. Although the establishment of medical laboratory institutions was a continuous process that matured only after the 16th century, several attempts had already been made to attain a diagnosis by investigating bodily excrement. In the first part of o...

Lanctôt, C.; Gauthier, Y.; Drouin, J., 1999: Pituitary homeobox 1 (Ptx1) is differentially expressed during pituitary development. Pituitary homeobox 1 (Ptx1) is a homeodomain-containing transcription factor acting on transcription of all pituitary hormone genes. Its expression is first detected in the stomodeal ectoderm and is maintained in all derivatives of this structure,...

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Scully, R., 2010: Cuts to council budgets may jeopardise health initiatives. NlmCategory="UNASSIGNED">Health campaigner Anne Diamond refers to Chinese takeaway businesses in Belfast that have reduced the amount of salt and fat in their food(reflections November 17).

Turner, T., 1989: Stand up for nursing. Nursing Times 85(28): 20-20

Hirschberg, W., 1994: Cognitive characteristics of children and adolescents with social behavior disorders--an overview. This paper first reviews studies that deal with intelligence structure and developmental disorders among children and adolescents with conducts disorders. Their intelligence quotients frequently fall in the dull normal range, they do worst on the...