geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immediate effects of captopril in acute left ventricular failure secondary to myocardial infarction


, : Immediate effects of captopril in acute left ventricular failure secondary to myocardial infarction. European Journal of Clinical Investigation 11(5): 369-373

In eight patients with acute left ventricular failure secondary to myocardial infarction the haemodynamic effects of captopril (25 mg), an orally active converting enzyme inhibitor, were measured. Haemodynamic modifications were maximal at 60 min and lasted for 2-3 h. Pulmonary wedge pressure fell from 23.5 +/- 4.9 (mean +/- SD) to 16.8 +/- 4.7 mmHg (P less than 0.01), cardiac output rose from 3.24 +/- 1 to 4.05 +/- 0.91 1/min (P less than 0.01). Systemic vascular resistance decreased from 27.34 +/- 3.81 to 17.52 +/- 1.65 mmHg min l-1 (P less than 0.01). Mean arterial pressure fell from 89.6 +/- 13.9 to 75.7 +/- 16.3 mmHg (P less than 0.001) while heart rate was not significantly modified. Six patients who had high pretreatment plasma renin activity values responded by a decrease in ventricular filling pressure and/or an increase in cardiac output. One patient with normal initial plasma renin activity value showed similar haemodynamic effects. THese data suggest that in the short term captopril is a vasodilator with both arterial and venous effects and improves cardiac function in acute left ventricular failure secondary to myocardial infarction.

US$29.90

PMID: 6800808


Other references

Basheev, V.Kh.; Marina, N.I.; Osaulenko, E.I.; Kuprienko, N.V., 1990: Association of adenocarcinoma of the large intestine and large intestine-uterine fistula. Klinicheskaia Khirurgiia: 40-41

MacArthur, C.J.; Wilmot, B.; Wang, L.; Schuller, M.; Lighthall, J.; Trune, D., 2013: Genetic susceptibility to chronic otitis media with effusion Candidate gene SNPs. The genetic factors leading to a predisposition to otitis media are not well understood. The objective of the current study was to develop a tag-single nucleotide polymorphism (SNP) panel to determine if there is an association between candidate g...

Isaacs, A.M.; Powell, C.; Webb, T.E.; Linehan, J.M.; Collinge, J.; Brandner, S., 2008: Lack of TAR-DNA binding protein-43 (TDP-43) pathology in human prion diseases. TAR-DNA binding protein-43 (TDP-43) is the major ubiquitinated protein in the aggregates in frontotemporal dementia with ubiquitin-positive, tau-negative inclusions and motor neurone disease. Abnormal TDP-43 immunoreactivity has also been describe...

Daiya, G.G., 1966: Redescription of Capillaria mergi and Thominx skrjabini (Nematoda: Capillariidae). Illustrated redescriptions of Capillaria mergi and Thominx skrjabini are given. In the USSR, C. mergi was recovered from Mergus albellus, M. merganser and M. serrator, and T. skrjabini from Cygnus olor, Anas acuta, A. penelope, A. platyrhynchos, A...

Rozo, G.J., 1969: Evaluating report on a continued program of addition of sodium fluoride in a suburb of Bogota, D.E. Revista de la Federacion Odontologica Colombiana 18(89): 57-62

Kustanovich, V.; Merriman, B.; Crawford, L.; Smalley, S.; Nelson, S., 2001: An association study of SNAP-25 alleles shows evidence for biased paternal inheritance in Attention Deficit Hyperactivity Disorder. American Journal of Human Genetics 69(4 Supplement): 582, October

Duby, J.J., 1995: Genetic discrimination. Science 270(5240): 1282-1282

Pelissier, A., 1948: Sur une epidemie de charbon humain en Basse Casamance. 14 cases of human anthrax with 4 deaths are reported from Bignona, Senegal. The outbreak was associated with an epizootic among cattle and sheep. 4 cases were treated with sulfonamides with uncertain results.

Matsunaga, Nobuo, 2002: Participation of hepatic stellate cells in inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. Proceedings of the American Association for Cancer Research Annual Meeting 43: 11, March

Andrade, C.; Reddy, K.P.; Srihari, B.S.; Sudha, S.; Chandra, J.S., 2000: Effects of zopicloone and Lorazepam on ect seizure duration : clinical implications of findings from an animal model. Lorazepam is commonly prescribed to treat insomnia in depressed patients who receive electroconvulsive therapy (ECT); however, lorazepam may interfere with ECT seizure parameters, and may thereby compromise the efficacy of the treatment. This stud...