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In vitro-initiated secondary anti-hapten response. II. Increasing cell avidity for antigen

, : In vitro-initiated secondary anti-hapten response. II. Increasing cell avidity for antigen. Journal of Experimental Medicine 132(5): 926-940

Decreasing antigen in vivo may preferentially stimulate cells with the potential for synthesis of high-affinity antibody through activation of surface receptors with similarly high affinity. This selection should result in cells with increased sensitivity to lower antigen concentrations, cells with greater avidity for antigen. We have followed the in vivo changes in anti-TNP memory-cell sensitivity by initiating the secondary anti-hapten response in vitro. This response was determined by anti-TNP plaque assay. The results indicate that cell populations with increased sensitivity for antigen continue to emerge with time after priming and that this sensitivity may increase 1000-fold in a 4 month period. Increased sensitivity to stimulation by antigen is concomitant with suppression by higher, previously stimulatory doses as in high zone immune tolerance. The data support the hypothesis that memory cells of high avidity result from the selective pressure of diminishing in vivo antigen concentration.


PMID: 5528414

Other references

Morey, RJ., 1978: Feeding preference and development of Aulacophora spp. on various cucurbitaceous hosts and phytotoxicity of some modern insecticides to cucurbits. Thesis Abstracts Haryana Agricultural University, 44: 293-294

Lenz, G.; Hutter, G.; Hiddemann, W.; Dreyling, M., 2004: Promoter methylation and expression of DNA repair genes hMLH1 and MGMT in acute myeloid leukemia. DGene silencing of DNA repair genes hMLH1 and MGMT caused by aberrant promoter methylation has been detected in various solid tumors. However, in acute myeloid leukemia (AML) the frequency of hMLH1 and MGMT promoter methylation is not yet fully el...

Imren H., 1975: The effect of high parenteral dosages of folic acid on carbohydrate metabolism. Istanbul Universitesi Tip Fakultesi Mecmuasi: 34-37

Badawy, A.A.; Evans, M., 1983: Naloxone in ethanol intoxication. Annals of Internal Medicine 98(5 Pt 1): 672-672

Robbins, J.M.; Bridges, M.D.; Childers, E.M.; Harris, R.M.; McElfish, P.A., 2015: Lessons from Prenatal Care Provider-Based Recruitment into the National Children's Study. In response to recruitment difficulties experienced by the National Children's Study, alternatives to the door-to-door recruitment method were pilot tested. This report describes outcomes, successes, and challenges of recruiting women through...

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