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Interleukin 2-independent stimulation of rabbit chondrocyte collagenase and prostaglandin E2 production by an interleukin 1-like factor


, : Interleukin 2-independent stimulation of rabbit chondrocyte collagenase and prostaglandin E2 production by an interleukin 1-like factor. European Journal of Immunology 14(6): 490-495

In the present study, interleukin 1 (IL 1)-containing media from different sources, namely a murine macrophage cell line (P388D1), rabbit peritoneal macrophages, and human peripheral blood mononuclear cells, were compared for their effect on thymocyte proliferation and on collagenase and PGE2 secretion by chondrocytes. A high correlation was found between the enhancement of thymocyte proliferation and the induction of collagenase and PGE2 secretion by chondrocytes. Furthermore, a highly purified IL 1-like factor, namely mononuclear cell factor (MCF) was also active on chondrocytes. The addition of highly purified IL 2 to rabbit chondrocytes had no effect on collagenase and PGE2 secretion induced by IL 1-containing media. Our findings suggest that the factor which induced collagenase and PGE2 secretion by rabbit chondrocytes was an IL 1-like factor. Thus, collagenase secretion by chondrocytes may be used as an IL 2-insensitive assay for the detection of IL 1-like factors.

US$19.90

PMID: 6329770

DOI: 10.1002/eji.1830140603


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Drugova G.M.; Shcheglova T.P.; Skublov S.K.; Savel yeva T.E.; Krylov I.N., 1998: Geochemistry of garnet in metamorphic rocks. Study of the rare element geochemistry in garnets from metamorphic formations of the White Sea region, Keivskiy structural block, Baikal region and Transbaikalia allows one to reveal that contents of some rare elements (Cr, Co, V, Zr, Y) and their...

Venclauskas, L.; Maleckas, A.; Arcelus, J.I., 2017: European guidelines on perioperative venous thromboembolism prophylaxis: Surgery in the obese patient. : A systematic literature search was performed and patients were selected as obese patients undergoing bariatric surgery or obese patients undergoing nonbariatric surgical procedures. In addition, patients were stratified according to low risk of...

Wembonyama, O., 2002: Behavior of African mothers with regard to prescription of medications for sick children. The ability of parents to follow medical prescriptions is indispensable for proper management of sick children. Too often, the treatments prescribed are not correctly followed by African mothers. The physician should have time for careful and comp...

Yamanouchi, K.; Chino, F.; Kobune, F.; Kodama, H.; Tsuruhara, T., 1973: Growth of measles virus in the lymphoid tissues of monkeys. Journal of Infectious Diseases 128(6): 795-799

Turner, W., 1891: The Relations of the Dentary Arcades in the Crania of Australian Aborigines. Journal of Anatomy and Physiology 25(Pt 4): 461-472

Beĭer, T.V.; Siim, I.Kh.; Khamchison, U.M., 1978: Cytochemical study of various stages of life cycle of Toxoplasma gondii. 10. Phosphatases in the parasites during developmental stages in cat's intestines. Several methods of acid and alkaline phosphatese and ATPase detection using both natural and artificial substrates were applied to the intestinal stages of Toxoplasma gondii with negative results to reveal enzymatic activity in all the stages exce...

McWhirter, J.; McCann, D.; Coleman, H.; Calvert, M.; Warner, J., 2008: Can schools promote the health of children with asthma?. This report describes the evaluation of a whole-school intervention to improve morbidity and psychosocial well-being in pupils with asthma. In all, 193 children with asthma (7-9 years) from 23 primary/junior schools in the south of England partici...

Tafur, E.; Cohen, L.S.; Levine, H.D., 1964: The Normal Apex Cardiogram: Its Temporal Relationship To Electrical, Acoustic, And Mechanical Cardiac Events. Circulation 30: 381-391

Longo, S.; Palmeri, V.; Carolei, A.E., 2000: Biology of Charaxes jasius in citrus orchards of the Calabria Region (Lepidoptera Nymphalidae). Biological observations on C. jasius feeding on citrus cv. Washington Navel in the plain of Gioia Tauro (Province of Reggio Calabria), Italy were performed for 2 years. Thirty-seven eggs were isolated by means of tulle sacks and provided with enou...

Frassetto, F., 1942: Di una nuova ipotesi sulla, origine delle specie. Orientamente per la sistemitica dei Primati e dell'Uomo. Scientia Bologna, 727-8: 20-28