+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Intratympanic gentamicin treatment: preliminary results in two patients with Menière's disease

, : Intratympanic gentamicin treatment: preliminary results in two patients with Menière's disease. Journal of the American Academy of Audiology 6(3): 264-270

Menière's disease is a vestibular disturbance characterized by episodic vertigo, tinnitus, and fluctuant hearing loss. The long-term effectiveness of available medical and nonablative surgical treatments has been variable, with frequent symptom recurrence. Vestibular neurectomy and labyrinthectomy, surgically ablative techniques, provide more permanent relief from vertiginous attacks. However, these procedures pose possible morbidity and cochlear risk. In this paper, preliminary results are presented for two patients who underwent intratympanic gentamicin application. Like surgical labyrinthectomy, intratympanic use of gentamicin is intended as an ablative procedure, but with potentially less risk to hearing. More vestibulotoxic than cochleotoxic, gentamicin initially disrupts the endolymph-secreting vestibular dark cells, thereby preventing endolymphatic hydrops development. Following gentamicin application, both patients demonstrated a significant change in peripheral vestibular function, as characterized by a reduction of caloric response, impaired posturography performance, and reduced low-frequency gain on rotary chair testing. Posturography performance subsequently improved, confirming functional compensation. Both patients reported relief from vertiginous attacks. However, word recognition ability was significantly worse in one of these two patients. Changes in pure-tone thresholds were minimal.


PMID: 7620206

Other references

Waterman, I.J.; Price, N.T.; Zammit, V.A., 2002: Distinct ontogenic patterns of overt and latent DGAT activities of rat liver microsomes. We have studied the ontogeny of the two functional diacylglycerol acyltransferase (DGAT) activities (overt and latent) during postnatal development in rat liver. We find that the ontogenic patterns of the two are highly distinct. Overt DGAT shows...

Ahrens, H.; Bernhardt, F., 2000: Effects of additional environmental constraints on agriculture, with special reference to Saxony/Germany. For appropriate decisions on the future shape of agri-environmental policy, politicians need information on the approximate ecological and economic consequences of additional environmental constraints on agriculture. This paper examines, on the ba...

Jo, J.; Kim, J.Ho.; Kim, J.Young.; Hyun, C.; Rhee, J.; Kwon, J.; Han, S.; Kim, W., 2015: Pazopanib for Non-small Cell Lung Cancer: The First Case Report in Korea. Pazopanib is a potent multitargeted tyrosine kinase inhibitor that has been shown to have good efficacy in patients with renal cell carcinoma. A previous phase II trial demonstrated that short-term pazopanib administration was generally well toler...

Hertzog, A.J.; Sether, J., 1947: Case for diagnosis; thrombosis of left renal artery with acute infarction of left kidney. Minnesota Medicine 30(7): 765-765

Van Eyndhoven, G.L., 1956: Modern Views on the Systematics of the Genus Bryobia. It is stated from further examination of material that the forms of Bryobia praetiosa that occur on gooseberry, fruit trees and grass also represent distinct species.

Bushnell, P.G.; Jones, D.R.; Farrell, A.P., 1992: The arterial system. Hoar, W S [Editor], Randall, D J [Editor], Farrell, A P [Editor] The Cardiovascular System, Vol XII Part A; Fish physiology : 89-139

Chang, K.S.Francis, 1937: Notes on the Eumastacinae from China with description of one new genus and two new species. Only 4 genera and spp. have previously been recorded from China, Butania lugubris, Bennia innotata, China mantispoides, and Erianthus versicolor. PIELOMASTAX (p.40), type P. octavii* (p.44), Kiangsi, including also P. soochowensis* (p.45), Kiangsu...

Chen, W.; Li, S.; Li, Y.; Wang, Y., 2008: Medial epicanthoplasty using the palpebral margin incision method. Epicanthal deformity is one of the most frequently encountered cosmetic problems in Asian people. Herein, we introduce a new method for correction of epicanthal folds, which always is performed in combination with double eyelidplasty. First, throu...

Gureva, EL., 1973: The chick-beetles (Coleoptera, Elateridae) of the Mongolian People's Republic. Nasekomye Mongol, 11: 455-474

Lamberg, B.A.; Karkinen-Jääskeläinen, M.; Franssila, K.O., 1989: Differentiated follicle-derived thyroid carcinoma in children. Fifteen patients, 11 females and 4 males, aged 4-16 years with follicle-derived differentiated thyroid carcinoma treated at the Helsinki University Central Hospital during 1953 through 1984 are reported. Histologically 13 carcinomata were papillar...