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Intravaginal PGE2 in early abortion


, : Intravaginal PGE2 in early abortion. Prostaglandins 7(2): 149-163

Intravaginal prostaglandin E2 (PGE2) was administered to 10 women in early (less than 50 days) pregnancy. Complete abortion was affected in 8, an incomplete abortion in 1, and 1 was a failure. Significant systemic side effects were noted in all subjects. Urinary hcG excretion rates prior to and on the 2nd and 14th day after PGE2 showed a decrease in all successfully aborted subjects and an initial decrease but a subsequent rise in the failure subject. Plasma concentrations of progesterone and estradiol-17 Beta showed no significant alterations during the early (less than 2 hours) administration of PGE2 but decreased significantly in all subjects just prior to expulsion, and at intervals thereafter. Estradiol-17Beta and progesterone alterations appeared to parallel each other indicating a common source, the corpus luteum. The mechanism by which PGE2 may effect early abortion is discussed.

US$29.90

PMID: 4852554


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