+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lactic acidosis, a complication of papaverine overdose

, : Lactic acidosis, a complication of papaverine overdose. Clinical Toxicology 18(4): 417-423

A 61-year-old female developed severe lactic acidosis after ingesting approximately 15 g of papaverine. This was associated with intense respiratory alkalosis, elevated plasma pyruvate, mild hyperglycemia, and hypokalemia. Severe lactic acidosis with elevated plasma pyruvate level and profound respiratory drive observed in this patient can be explained by the inhibition of mitochondrial oxidative reactions by papaverine. The clinical and biochemical features of papaverine-induced acid-base disturbance closely resemble those caused by salicylates, another known mitochondrial toxin.


PMID: 7248034

DOI: 10.3109/15563658108990265

Other references

Diamond, G.A.; Forrester, J.S.; deLuz, P.L.; Wyatt, H.L.; Swan, H.J., 1978: Post-extrasystolic potentiation of ischemic myocardium by atrial stimulation. The response of acutely ischemic myocardium to post-extrasystolic potentiation (PESP) was evaluated in 11 mongrel dogs. Mercury-in-silastic length gauges were sutured to the epicardial surface of the left ventricle; left ventricular pressure was d...

Hartz T.K.; Smith R.F.; Schrader W.L., 1992: Comparison of in field techniques for monitoring plant and soil nitrogen status. Hortscience 27(6): 571

Speece, Re, 1973: Trout metabolism characteristics and the rational design of nitrification facilities for water re-use in hatcheries. Transactions Am Soc: 323-334

Pédrot, M.; L.B.udec, A.; Davranche, Mélanie.; Dia, A.; Henin, O., 2011: How does organic matter constrain the nature, size and availability of Fe nanoparticles for biological reduction?. Few studies have so far examined the kinetics and extent of the formation of Fe-colloids in the presence of natural organic ligands. The present study used an experimental approach to investigate the rate and amount of colloidal Fe formed in prese...

Darlow, H.M., 1949: Observations on the genus Euphaedra Hubn. (Lep. Rhop.) in Sierra Leone. Entomologist London, 82: 193-200

Shaw D.M.; Middleton T.A.; Smith P.A., 1989: Lunar boron, samarium, gadolinium correlations. LPI Contribution 712: 222

Bailey, H.A.; Dumas, L.W.; Lackey, R.W., 2011: The relation of physiologic variables to circulation time. Journal of Laboratory and Clinical Medicine 31: 584-588

Margolis, M.T.; Thoen, L.D.; Wheeless, C.R.; Mercer, L.J., 1996: Rabbit fallopian tube reanastomosis using a microvascular stapling device. The 3M Precise Microvascular Anastomotic System (MAS), a microvascular stapling device, was compared with microsurgery for the reanastomosis of rabbit fallopian tubes. Differences in operative time, tubal patency, adhesion formation, and fertility...

Sesana, G.; Cortona, G.; Baj, A.; Quaianni, T.; Colombo, E., 1994: Cobalt exposure in wet grinding of hard metal tools for wood manufacture. The authors examined exposure to cobalt during the wet grinding of hard metal tools (Widia tools) used in the wood industry, usually in small specialized workshop which can produce exposure to cobalt > TLV-TWA (50 micrograms/m3) if carried out...

A.M.M.N.cholas; D.C.F.anklin; D.M.J.S.B.wman, 2011: Floristic uniformity across abrupt boundaries between Triodia hummock grassland and Acacia shrubland on an Australian desert sandplain. The tension between pyrophytic hummock grasslands and fire-sensitive mulga shrubland is a major ecological theme in central Australia. On a sandplain on the edge of the Tanami Desert, grassland and shrubland are juxtaposed with abrupt boundaries t...