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Lorazepam in children. A double-blind trial comparing lorazepam, diazepam, trimeprazine and placebo

, : Lorazepam in children. A double-blind trial comparing lorazepam, diazepam, trimeprazine and placebo. British Journal of Anaesthesia 55(4): 275-279

One hundred patients aged 5-13 yr were randomly allocated to four groups in a double-blind study of premedication. Drugs studied were lorazepam, diazepam and trimeprazine. A placebo group was included. All the drugs appeared satisfactory as premedicants. Lorazepam induced the most sedation immediately after surgery, but by 4 h lorazepam and diazepam appeared similar. Lorazepam produced better amnesia than the other drugs. There were no untoward side-effects and no cardiorespiratory depression in any group. Lorazepam appears a suitable premedicant for children.


PMID: 6132612

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