geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Low density lipoprotein receptors in cultured skin fibroblasts from psoriasis patients


, : Low density lipoprotein receptors in cultured skin fibroblasts from psoriasis patients. Clinical Genetics 25(3): 230-241

Low density lipoprotein (LDL) receptor activity, measured as 125I-LDL association and degradation at 37 degrees C, was determined in cultured fibroblasts from involved as well as uninvolved skin obtained from 20 psoriasis patients. The same analyses were conducted in fibroblasts from two reference groups consisting of 19 heterozygotes for familial hypercholesterolemia and 16 normal subjects, respectively. Psoriasis patients had significantly lower LDL receptor activity than normals, and it was comparable to that of the heterozygotes for familial hypercholesterolemia. The reduced LDL receptor activity was not accompanied by an increase in total serum cholesterol. The psoriasis patients had a significant reduction in apo-B concentration, but did not differ from the normals in the other serum lipid or lipoprotein parameters. There was no difference in LDL receptor activity between involved and uninvolved skin from psoriasis patients. These results suggest that there is an abnormal cell membrane in dermal fibroblasts from psoriasis patients. Since their total serum cholesterol is normal, their low LDL receptor activity may be confined to dermal cells, leaving the hepatic lipid metabolism normal. The pathogenetic significance of this finding is unknown.

US$29.90

PMID: 6323070


Other references

Anonymous, 1998: Waste Management: EU Parliament strengthens draft landfill law. Environmental Science & Technology 32(7): 170a-170a

Correia, Iês.; Alonso-Monge, R.; Pla, Jús., 2017: The Hog1 MAP Kinase Promotes the Recovery from Cell Cycle Arrest Induced by Hydrogen Peroxide in iCandida albicans. Eukaryotic cell cycle progression in response to environmental conditions is controlled via specific checkpoints. Signal transduction pathways mediated by MAPKs play a crucial role in sensing stress. For example, the canonical MAPKs Mkc1 (of the c...

Hartmann, J.; Kilian, M.; Atanassov, V.; Braumann, C.; Ordemann, J.; Jacobi, C.A., 2008: First surgical tumour reduction of peritoneal surface malignancy in a rat's model. Surgical therapy of peritoneal surface malignancy from colorectal origin in combination with Hyperthermic Intraoperative Peritoneal Chemotherapy (HIPEC) has now become an established treatment approach in very few specialised centres. A peritonec...

Landini, M.P.; Mirolo, G.; Coppolecchia, P.; Re, M.C.; L.P.aca, M., 1986: Serum antibodies to individual cytomegalovirus structural polypeptides in renal transplant recipients during viral infection. In a longitudinal study we examined by immunoblotting (IB) the development and the evolution of the humoral immune response against individual cytomegalovirus (CMV) structural polypeptides in a total of 80 serum samples from 13 renal transplant re...

Pfeiffer, K.E.; Jury, L.J.; Larson, J.E., 2014: Determination of anti-Müllerian hormone at estrus during a synchronized and a natural bovine estrous cycle. Anti-Müllerian hormone (AMH) has been correlated with phenotypic indicators of fertility. However, the effects of exogenous hormones used during estrus synchronization on AMH have not been evaluated. Therefore, the objective of this experiment wa...

Somer G.; Temizer A., 1984: Photoreduction of thionine by water. The photoreduction of thionine by water has been studied, using a technique applied in earlier work on photoreduction of methylene blue. A long-lived excited intermediate is formed, and 2 such intermediates react to produce a single reduced molecu...

Pratt, M.L.; DeMoss, J.A., 1988: Neurospora tryptophan synthase. Characterization of the pyridoxal phosphate binding site. Tryptophan synthase, which catalyzes the final step of tryptophan biosynthesis, is a multifunctional protein that requires pyridoxal phosphate for two of its three distinct enzyme activities. Tryptophan synthase from Neurospora crassa, a homodimer...

Gapin, L.; Cabaniols, J.P.; Cibotti, R.; Ojcius, D.M.; Kourilsky, P.; Kanellopoulos, J.M., 1997: Determinant selection for T-cell tolerance in HEL-transgenic mice: dissociation between immunogenicity and tolerogenicity. The induction of T-cell tolerance to self-antigens has been extensively characterized for immunodominant (ID) regions. However, tolerance toward other minor self-determinants has received less attention. In the H-2(d) haplotype, HEL contains a sin...

Yan, X.; Zhou, M.; Ying, L.; Liu, W.; Yang, G.; Wu, D.; Zhou, Y.; Peterson, B.S.; Xu, D., 2015: A fast schema for parameter estimation in diffusion kurtosis imaging. Diffusion kurtosis imaging (DKI) is a new model in magnetic resonance imaging (MRI) characterizing restricted diffusion of water molecules in living tissues. We propose a method for fast estimation of the DKI parameters. These parameters - apparen...

Tsanev, R.G.; Tsanev, R.G., 2009: From chemical embryology to nucleosome patterning - an interview with Roumen G. Tsanev. Roumen Tsanev was a prominent Bulgarian scientist whose pioneering ideas about the role for chromatin in cell differentiation and development led him to propose the first hypothesis for epigenetic information based on a histone code. To test exper...