geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Morphological studies on neuroglia. VI. Postnatal development of microglial cells


, : Morphological studies on neuroglia. VI. Postnatal development of microglial cells. Cell and Tissue Research 225(3): 469-485

The postnatal development of microglial cells was investigated in the neonatal rat brain by use of light- and electron microscopy, including enzyme-histochemical techniques. Microglial cells were selectively stained by demonstration of their nucleoside diphosphatase (NDPase) activity and classified into three types: 1) In the early postnatal period "primitive microglial cells" showing scantily ramified processes were found in the cerebral cortex, the hippocampal formation, and the hypothalamus. During the course of the first postnatal week the processes of this cell type developed gradually and the cells were transformed into typical ramified microglial cells, called "resting microglial cells". 2) "Amoeboid microglial cells "showing typical features of macrophages were characteristic of the cerebral white matter. 3) "Round microglial cells" possessing a round soma and few pseudopodia but no characteristic processes occurred in large numbers in the subventricular zone of the lateral ventricle and as single elements in the vicinity of blood vessels. Histochemically, thiamine pyrophosphatase (TPPase) was demonstrated only in the fully developed, ramified microglial cells ("resting microglial cells"), which could be readily observed in the central nervous tissue from the age of 14 day. "Round and amoeboid microglial cells" did not show TPPase activity and disappeared after 14 days of postnatal life. By use of electron microscopy, in neonatal rats NDPase activity was apparent in the plasma membrane of the three types of microglial cells ("primitive, round, and amoeboid" types). They showed basically similar submicroscopic characteristics, i.e., well-developed Golgi apparatus, long strands of rough-surfaced endoplasmic reticulum, single dense bodies and vacuoles, and numerous ribosomes. "Amoeboid microglial cells" were characterized by their well-developed cytoplasmic vacuoles and phagocytic inclusion bodies. The present study strongly suggests a mesodermal origin for these microglial elements.

US$29.90

PMID: 6290069


Other references

Sproviero, E.M.; Gascón, Jé.A.; McEvoy, J.P.; Brudvig, G.W.; Batista, V.S., 2008: A model of the oxygen-evolving center of photosystem II predicted by structural refinement based on EXAFS simulations. A refined computational structural model of the oxygen-evolving complex (OEC) of photosystem II (PSII) is introduced. The model shows that the cuboidal core Mn3CaO4 with a "dangler" Mn ligated to a corner mu4-oxide ion is maximally consi...

Abramson, R.K.; Hall, A.; Ravan, S.A.; Cuccaro, M.L.; Wolpert, C.M.; Pericak Vance, M.A.; Wright, H.H., 2003: A comparison of a measure of hyperactivity/impulsivity in individuals with Autistic Disorder versus Asperger Disorder. American Journal of Medical Genetics 122B(1): 77-78, September 15

Celuch, S.M.; Sloley, B.D., 1989: Release of 5-hydroxytryptamine, dopamine and noradrenaline in the rat vas deferens in the presence of compound 48/80, veratridine or K+. 1. The release of 5-hydroxytryptamine (5-HT), dopamine and noradrenaline (NA) from the rat isolated vas deferens was estimated by high performance liquid chromatography with electrochemical detection. 2. Compound 48/80, which is known to release 5...

Saha, B.C.; Lecureux, L.W.; Zeikus, J.G., 1988: Raw starch adsorption-desorption purification of a thermostable beta-amylase from Clostridium thermosulfurogenes. The beta-amylase from Clostridium thermosulfurogenes was readily adsorbed onto raw starch. The adsorbed beta-amylase was eluted from raw starch by using boiled soluble starch solution as an elutant. The soluble starch treated beta-amylase could no...

Lode, T., 1990: Le regime alimentaire d'un petit carnivore, le putois (Mustela putorius) dans l'ouest de la France. The study of Polecat (Mustela putorius) food habits based on the analysis of 567 faeces, reveals seasonal variations in the diet. Amphibians make up 23% of the annual diet but totalize 55% of the food in March. Rodents (Norway rat and voles) may m...

Li, Z.; Wang, L., 1991: Agriculture and forestry insect fauna of Guizhou Vol 4 Homoptera Cicadellidae. Unknown

Cape E.G.; Yoganathan A.P.; Rodriguez L.; Weyman A.E.; Levine R.A., 1990: The proximal flow convergence method can be extended to calculate regurgitant stroke volume in vitro application of the color doppler m mode. Journal of the American College of Cardiology 15(2 SUPPL A): 109A

Baillot, Aélie.; Mampuya, W.M.; Dionne, I.J.; Comeau, E.; Méziat-Burdin, A.; Langlois, M-France., 2016: Impacts of Supervised Exercise Training in Addition to Interdisciplinary Lifestyle Management in Subjects Awaiting Bariatric Surgery: a Randomized Controlled Study. Experts recommend physical activity (PA) to optimize bariatric surgery (BS) results. However, evidence on the effect of PA before BS is missing. The aim of this study was to assess the impact of adding a Pre-Surgical Exercise Training (PreSET) to...

Malicky H., 1980: Evidence for seasonal migrations of larvae of 2 species of philopotamid caddis flies trichoptera in a mountain stream in lower austria. Field research with emergence traps suggests that the larvae of Philopotamus ludificatus Mcl. and Wormaldia copiosa Mcl. migrate upstream in winter and downstream in summer. These migrations, which appear to be determined by daylength, are directe...

Pacheco-Rupil, B.; Depiante-Depaoli, M.; Martínez, L.; Casas, A., 1984: Polyacrylamide gel electrophoretic abnormalities in breast carcinoma patients: suppressive effect upon PHA-induced leucocyte migration inhibition by an isolated serum fraction. Cellular and Molecular Biology 30(3): 179-188