+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Neural elements containing glutamic acid decarboxylase (GAD) in the dorsal lateral geniculate nucleus of the rat; immunohistochemical studies by light and electron microscopy

, : Neural elements containing glutamic acid decarboxylase (GAD) in the dorsal lateral geniculate nucleus of the rat; immunohistochemical studies by light and electron microscopy. Neuroscience 8(2): 189-211

Immunoreactive constituents of the dorsal lateral geniculate nucleus of adult albino rats were examined by light- and electron-microscopy, using the unlabelled antibody enzyme method, following treatment of brain slices with a purified antibody to glutamic acid decarboxylase. The neuropil of the dorsal lateral geniculate nucleus displayed a conspicuous granular immunoreactivity. In addition, the antibody was bound to a class of small neurons of characteristic morphology. These cells possessed few (commonly 2-4) sparsely branched, long dendrites from some of which immunoreactive appendages were traced. Many cells were bipolar in form, and the dendrites of some appeared to be preferentially orientated. The immunoreactive cells closely resembled intrinsic interneurons characterized in previous Golgi studies of this nucleus. By electron-microscopy, immunoreactive presynaptic elements were present both in the extraglomerular neuropil and in the synaptic glomeruli. The former were axon terminals containing flattened synaptic vesicles and making Gray type II axo-dendritic synaptic contact; they appeared to correspond to axon terminals whose origin in the thalamic reticular nucleus has been established in previous studies, but it is possible that some were axon terminals of intrinsic interneurons. The immunoreactive glomerular components also contained flattened vesicles, were presynaptic to presumptive projection cell dendrites, postsynaptic to retinal axon terminals, and participated in triplet (triadic) and other complex synaptic arrangements. They corresponded in all respects to the synaptic portions of the complex dendritic appendages of intrinsic interneurons, identified and characterized in previous studies. The finding that there are high levels of glutamic acid decarboxylase in the cell bodies, dendritic shafts and dendritic appendages of intrinsic interneurons in the dorsal lateral geniculate nucleus of the rat, and in the axon terminals of fibres projecting to this site from the thalamic reticular nucleus, allows us to conclude that the inhibitory inputs to the geniculo-cortical projection cells from both of these sources are probably mediated by gamma-aminobutyric acid.


PMID: 6341876

Other references

Desai, A.K.; Osahan, D.S.; Undavia, M.B.; Nair, G.B., 2016: Bronchial injury post-cryoablation for atrial fibrillation. Annals of the American Thoracic Society 12(7): 1103-1104

Faĭtel'berg, R.O.; Gladkiĭ, T.V., 1979: Effect of motion sickness on the absorption of B group vitamins and ascorbic acid in the small intestine of dogs. On the dogs with a Thiry-Pavlov fistula (an isolated loop of the small intestine) the effect of 30-min acceleration on the absorption of thiamine-bromide, riboflavine, pyridoxine-hydrochloride and ascorbic acid as well as on the gastric juice secr...

Kruger, A.; Freeman, J.; Chapman, R.; Hamblin, T.; Oscier, D., 1994: Comparison of scoring systems for prognosis in MDS. Leukemia Research 18(SUPPL ): 40

Khalil, D.A.; Lucas, E.A.; Smith, B.J.; Soung, D.Y.; Devareddy, L.; Juma, S.; Akhter, M.P.; Recker, R.; Arjmandi, B.H., 2004: Soy isoflavones may protect against orchidectomy-induced bone loss in aged male rats. Evidence from several studies suggests that soy protein and/or its isoflavones may have beneficial effects on bone in postmenopausal women and animal models who have osteoporosis. The present study examined the dose-dependent effects of soy isofla...

Baguen, C.Ndela, J.; Cost, T.Lens, P.; Esquerd, M.Nez, J., 1962: Hypopituitarism, neurofibromatosis (incomplete form) and muscular atrophy. Medicina Espanola 47: 211-216

Van Le, L.; McCormack, M., 2016: Enhancing Care of the Survivor of Gynecologic Cancer: Managing the Menopause and Radiation Toxicity. It is expected that there will be 290,000 cases of gynecologic cancers in 2016. Of these cancers, 60,000 will be endometrial and 22,000 will be ovarian-the two most common gynecologic cancers. Endometrial and ovarian cancers occur in menopausal wo...

Schneiderman, M.A., 1974: Digestive system cancer among persons subjected to occupational inhalation of asbestos particles: a literature review with emphasis on dose response. Human data show a dose-response relationship between industrial exposure to asbestos and later development of cancer of the bronchus and lung and of cancer of the digestive tract. The data do not provide much evidence for a threshold or for the ex...

Rasi S.J.; Suvanto E.; Vilpo L.M.; Vilpo J.A., 1989: Rapid and sensitive fluoroimmunoassay of dna methylation. Journal of Cellular Biochemistry Supplement (13 PART D): 225

Stanisic, M.; Bijeljac, S.; Saric, Z.; Jovanovic, S., 1990: Correlative relations in technology of kajmak. This investigation was undertaken to ascertain if quality and quantity of kajmak depend on the quality of milk and other factors. The investigation was carried out in a mountainous area of Yugoslavia and included kajmak samples of 4 producers. In...

Arolt, V., 1994: Psychotherapy of depression in general practice of established psychiatrists: results of an empirical study. A severe deficit in studies providing a valid assessment of indication of psychotherapy in different population samples and care settings must be stated for the FRG. Actual decisions in health care politics are not supported by sufficient empirica...