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Neural response of carotid chemoreceptors following dopamine blockade


, : Neural response of carotid chemoreceptors following dopamine blockade. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 50(1): 172-177

The role of endogenous carotid body dopamine in the afferent chemoreceptor circuit was studied by means of haloperidol-induced dopamine antagonism. In 19 cats that were anesthetized with pentobarbital sodium and paralyzed, single carotid body nerve fibers were dissected free and placed on unipolar platinum wire electrodes. In 10 of these cats, the neural response to room air and the last 2 min of 6-min inhalations of 3, 6, and 9% CO2 were recorded, and blood samples were drawn for gas tension measurements. Haloperidol was administered at a dose (250 micrograms/kg) shown to block the inhibitory effect of injected dopamine. Following a 15-min equilibration, the CO2 response was again tested. In four other cats the CO2 response was tested with a hyperoxic background. In the remaining five cats the response to isocapnic hypoxia was recorded during administration of 15, 12, and 8% O2 before and following haloperidol. There was a significant increase in room air discharge activity and in hypoxic sensitivity following haloperidol. However, there was no significant change in hypercapnic sensitivity. These results suggest that there is a modulatory role for endogenous dopamine only in the hypoxic response.

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PMID: 6782052


Other references

Wood, M.J.; Candy, C.J.; Whittingham, D.G., 1996: Cryopreservation of mouse oocytes in propylene glycol and ethylene glycol. Cryobiology 33(6): 662-663

Adachi, M.; Motohashi, M., 2015: Images in clinical medicine. Passage of a sialolith. New England Journal of Medicine 372(11): E15-E15

Hugo W.B.; Bloomfield S.F., 1971: Studies on the mode of action of the phenolic anti bacterial agent fentichlor against staphylococcus aureus and escherichia coli part 3 the effect of fentichlor on the metabolic activities of staphylococcus aureus and escherichia coli. Journal of Applied Bacteriology 34(3): 579-591

Habiba, L.; Hassib, B.; Moktar, H., 2008: Improvement of activated sludge stabilisation and filterability during anaerobic digestion by fruit and vegetable waste addition. Anaerobic co-digestion of fruit and vegetable waste (FVW) and activated sludge (AS) was investigated using anaerobic sequencing batch reactors (ASBRs). The effects of AS:FVW ratio and the organic loading rate (OLR) on digesters performances were e...

Sanchez I.; Aguirre J., 1996: Diagenetic origin of carbonate cements in sandstone nodules, Pliocene of Lebrija, Seville. Geogaceta 20(3): 674-676

Degelius G., 1968: Findings of lichens interesting from a plant geographic point of view. Svensk Botanisk Tidskrift 62(2): 405-409

Rogausch, H., 1976: Time-dependent reaction of human red cell deformability on sphering agents. The viscosity of samples with normal and normovolemic sphered erythrocytes was tested, using high- and low-shear capillary viscometry, paper filtration of packed red blood cells, and low g-value centrifugation. Incubated serum, pure lysolecithin a...

Viladomat, G.C.; Angeles, O.T.; Sagahon, V.L.; Machin, J.; Jacobs, J.A.C.; Amaya, M.G.; Carrasco, A.C., 1988: Drug resistance not codified by plasmids in Actinobacillus pleuropneumoniae serotype 1. The in vitro sensitivity of 20 isolates of Actinobacillus pleuropneumoniae serotype 1 from abattoir pigs with chronic contagious porcine pleuropneumonia was studied together with the presence of plasmids. Sensitivity was ascertained by the agar di...

Rosen B.U.M.; Rosenthal I., 1989: Evaluation of clostridia in raw milk. Clostridium tyrobutyricum is the main microorganism responsible for late blowing deterioration of cheese. Clostridia can readily be detected in raw milk, by MPN method, using a reinforced clostridial medium with lactate substituted for glucose. In...

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