+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Partial deficiency of the fourth component of human complement (C4) and autoantibody directed against C4 in a patient with SLE

, : Partial deficiency of the fourth component of human complement (C4) and autoantibody directed against C4 in a patient with SLE. Annales D'immunologie 134d(2): 233-245

The finding of dramatically depressed levels of C4 in a 17-year old patient with severe systemic lupus erythematosus (SLE) prompted a genetic study of her family. This study revealed the existence of a partial C4 deficiency; we found the presence of a C4A3,C4BQo haplotype which was transmitted by the mother to each of her children. This patient possessed, in her serum, an autoantibody with anti-C4 specificity. The immunochemical characterization of this autoantibody revealed that it was IgM and belonged to the immunoconglutinin family. We have studied the effects of this autoantibody on the formation and dissociation kinetics of classical C3-convertase.


PMID: 6559049

Other references

Coles, J.H., 1974: Joseph Harry Coles. Medical Journal of Australia 2(24): 884-884

Hawthorne A.R.; Gammage R.B., 1982: Formaldehyde release from simulated wall panels insulated with urea formaldehyde foam insulation. An important potential source of formaldehyde in the home is urea-formaldehyde foam insulation (UFFI). The long-term release of formaldehyde through the interior wall of test panels foamed with commercial urea-formaldehyde insulation was measured....; Tian Yu; Song Houyan; Zhu Yunsong, 1999: Plasminogen activator inhibitor type 2 inhibits tumor necrosis factor alpha-induced apoptosis. Purpose: To investigate the mechanism of PAI-2 in the inhibition of apoptosis induced by TNFalpha and cycloheximide. Methods: Various apoptosis determination methods were used to identify the model of HeLa cell apoptosis initiated by TNFalpha and...

Myers, C.S., 1941: Aspects Of Modern Psychology. Ii. Science 94(2431): 102-105

Hart Jane K., 1995: Drumlin formation in southern Anglesey and Arvon, Northwest Wales. JQS: al of Quaternary Science. 10; 1, Pages 3-14. 1995.

Wig, N.N.; Pershad, D.; Isaac, R.P., 1973: A prospective study of symptom and non-symptom groups following vasectomy. Indian Journal of Medical Research 61(4): 621-626

Febrer, E.; Mestres, M.; Caballín, Mía.Rosa.; Barrios, L.; Ribas, M.; Gutiérrez-Enríquez, S.; Alonso, C.; Ramón y Cajal, T.; Francesc Barquinero, J., 2008: Mitotic delay in lymphocytes from BRCA1 heterozygotes unable to reduce the radiation-induced chromosomal damage. Double strand breaks (DSB) are critical lesions involved in the formation of chromosomal aberrations. In response to DNA damage, the cell has mechanisms of repair and cell-cycle control to maintain the genome integrity in which BRCA1 gene is impli...

Tang M.; Shang J.Q., 2000: Vacuum preloading consolidation of Yaoqiang Airport runway. Yaoqiang Airport is an international airport serving the city of Jinan, China. The soil on the site consists of alternate layers of silty sand, silty clay, slit and clay. An underconsolidaed soft clay layer approximately 4 m thick is located at be...

Anonymous, 2001: 2nd Annual International Motor City Diabetes Symposium. Journal of Diabetes & its Complications 15(1): 1-56, January-February

Robertson, H.A.; David, J.C.; Danielson, T.J., 1977: Effects of de nervation on the levels of p octopamine m octopamine norphenylephrine and phenyl ethanolamine in rat salivary gland/. A sensitive, specific radiochemical-enzymatic assay which allows the simultaneous determination of m-octopamine, p-octopamine and phenylethanolamine levels in tissues was developed. This technique was used to reinvestigate the problem of extranora...