geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Photophysical, photochemical and photobiological studies of 4'-methylangelicins, potential agents for photochemotherapy


, : Photophysical, photochemical and photobiological studies of 4'-methylangelicins, potential agents for photochemotherapy. Il Farmaco; Edizione Scientifica 39(1): 57-69

In order to study the relationship between certain photophysical and photochemical properties of furocoumarins and their photobiological activities, the quantum yields of the formation of excited triplet states, the capacity to generate singlet oxygen in vitro and the effect of oxygen on photoinduced cell killing and on the induction of cytoplasmic "petite" mutations in Saccharomyces cerevisiae were determined for a series of 4'-methylangelicins and 3-carbethoxypsoralen (3-CPs). The capacity to generate singlet oxygen, in good agreement with the photophysical data, correlates well with the oxygen effect observed on the lethality of Saccharomyces cerevisiae shown by the various compounds and followed the ranking order 3-CPs greater than 4',4-dimethylangelicin greater than 4'-methylangelicin greater than 4',5-dimethylangelicin. On the other hand the oxygen effect on the induction of cytoplasmic "petite" mutations on yeast appears much less pronounced than that shown on survival. Concerning other photobiological properties previously studied no correlation was observed between the capacity to generate singlet oxygen in vitro and the skin photosensitizing activity of the compounds. Moreover, the generation of singlet oxygen by furocoumarins does not appear as the main cause for the photoinduction of skin tumors in mice.

US$29.90

PMID: 6368262


Other references

Rashmi,K.R.; Earanna,N., 2008: Response of Davana to biofertilizers treatment. Mysore Journal Of Agricultural Sciences: 4, 780-784

Dehmer, G.J.; Blankenship, J.C.; Cilingiroglu, M.; Dwyer, J.G.; Feldman, D.N.; Gardner, T.J.; Grines, C.L.; Singh, M., 2015: SCAI/ACC/AHA Expert Consensus Document: 2014 Update on Percutaneous Coronary Intervention Without On-Site Surgical Backup. Catheterization and Cardiovascular Interventions 84(2): 169-187

Wang, Z.; Zhu, H.; Dong, Y.; Wang, J.; Feng, G., 2001: Force-frequency coefficient of symmetrical incomplete circular quartz crystal resonator. The changes in the resonance frequencies of the thickness-shear vibration of symmetrical incomplete circular AT-cut quartz crystal resonators (QXRs), which are used as sensing elements in digital force sensors or pressure transducers, by the appli...

Kairouz, R.; Daly, R.J., 2001: Tyrosine kinase signalling in breast cancer: modulation of tyrosine kinase signalling in human breast cancer through altered expression of signalling intermediates. The past decade has seen the definition of key signalling pathways downstream of receptor tyrosine kinases (RTKs) in terms of their components and the protein-protein interactions that facilitate signal transduction. Given the strong evidence that...

Koenig, J.; D.L.P.rte, S.; Chapron, J., 1998: The Schwann cell at the neuromuscular junction. Synapses obtained in vitro in a system of co-culture of muscle cells and neurons are of embryonic type. We prepared a monoclonal antibody (6.17) which recognizes a molecule synthesized by Schwann cells and used it to show that the main characteris...

Shioda, A.; Moriyama, M.; Komine, F.; Suzuki, K.; Tanaka, N.; Okubo, H.; Ishizuka, H.; Arakawa, Y., 1996: Factors determining efficacy of interferon therapy for chronic hepatitis C. Gastroenterology 110(4 SUPPL ): A1323

Celada A.; Herreros V.; Donath A., 1981: Clinical evaluation of simultaneously administered cobalt 58 labeled vitamin b 12 and cobalt 57 labeled vitamin b 12 bound to intrinsic factor in patients with pernicious anemia. The clinical and laboratory data from 75 patients with altered vitamin B12 absorption were reviewed. In 36 cases the diagnosis of pernicious anemia had been established. Of these, 14 patients showed malabsorption of radiolabeled vitamin B12, but t...

Campo M.L.; Tedeschi H., 1984: Protonmotive force in giant mitochondria. The microinjection of the pH fluorescent indicator pyranine (8-hydroxy-1,2,6-pyrenesulfonate) into giant [mouse] mitochondria or mitoplasts does not affect their ability to carry out oxidative phosphorylation. The dye can therefore be used as a qu...

Iampol'skaia, V.D., 1957: Results of extrapleural pneumolysis in tuberculosis of the lower lobe in obliterated and free pleural cavity. Problemy Tuberkuleza 35(5): 30-33

Tyszkiewicz, E., 2017: Auditory Verbal Practice - Family-centered Early Intervention. Cochlear Implants International 18(6): 347-348