+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Prostaglandins, catecholamines, and cardiovascular responses to hemorrhage

, : Prostaglandins, catecholamines, and cardiovascular responses to hemorrhage. American Journal of Physiology 240(3): R166-R174

The effects of prostaglandins (PGE2 and 16,16-dimethyl-PGE1) on epinephrine (E) and norepinephrine (NE) release, in response to a hypotensive stimulus (bleeding 5 ml/300 g), were studied in relation to blood pressure and heart rate responses in the rat. PGE2 (10 micrograms/kg-1 . min-1) and 16,16-dimethyl-PGE1 (1 microgram . kg-1 . min-1) accelerated blood pressure and heart rate recovery rate following acute hemorrhage and increased plasma E and NE levels. Plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenylglycol (DHPG) were not affected by PG infusion. In bilaterally nephrectomized rats, PGE2 increased plasma levels of E, NE, and DHPG but failed to enhance the blood pressure and had only a mild effect on heart rate recovery following bleeding. In hexamethonium-treated rats, infusion of PGE2 had a small and transient effect on blood pressure recovery, but its effect on the heart rate was not affected; NE and E levels in the plasma of the hexamethonium-treated rats were still higher in the PGE2-infused rats. These studies indicate that in the intact rat, administered PGE potentiate the release of E and NE and facilitate blood pressure and heart rate recovery following acute hemorrhage. The hemodynamic effects of the PGE appear to be mediated by a renal factor whereas the effects of PGE on E and NE response to hemorrhage are independent of the presence of intact kidneys.


PMID: 7212088

Other references

Rhee K.S.; Dutson T.R.; Smith G.C., 1984: Enzymic lipid per oxidation in microsomal fractions from beef skeletal muscle. Enzymic lipid peroxidation in microsomes isolated from beef muscle (longissimus dorsi: LD) was demonstrated. The reaction required NADPH or NADH, ADP and Fe2+ or Fe3+. The optimum pH of the reaction was .apprx. 6.5. The rate of oxidation was highe...

Sehested, J.; Pedersen, R.E.; Strudsholm, F.; Foldager, J., 2003: The digestive physiology and nutrition of unweaned cows. Great emphasis is placed on the early feeding of newborn calves whose future wellbeing is determined to a large extent by the level of immunity that they acquire from colostrum at this time, and also on the development of their digestive system as...

Pepin H.S.; Prager C.M., 1990: Survey of preharvest and postharvest fungal diseases of cranberry fruit. Canadian Plant Disease Survey 70(1): 98

Betesta, C., 1965: Various orthodontic truths. Le Chirurgien-Dentiste de France 25(43): 23-25

Lopez, E.; Jarreau, P-Henri., 2014: Inflammation and bronchopulmonary dysplasia. Medecine Sciences 29(10): 823-825

Schindler, M., 1996: Costs of potato planting. Total fixed and variable costs in DM/ha for planting potatoes with two and four row fixed hopper machines and four, six and eight row tipping hopper machines are compared. Depending on the area to be planted, costs range from DM 163 to DM 351 per...

Seitz, R., 1955: Paradoxical vascular and pupillary reaction; experimental studies on rabbits' eyes. Klinische Monatsblatter für Augenheilkunde und für Augenarztliche Fortbildung 127(3): 316-334

Zirkle, M.; Roberson, D.W.; Leuwer, R.; Dubrowski, A., 2007: Using a virtual reality temporal bone simulator to assess otolaryngology trainees. The objective of this study is to determine the feasibility of computerized evaluation of resident performance using hand motion analysis on a virtual reality temporal bone (VR TB) simulator. We hypothesized that both computerized analysis and exp...

Nelson, T.; Lucignani, G.; Goochee, J.; Crane, A.M.; Sokoloff, L., 1986: Invalidity of criticisms of the deoxyglucose method based on alleged glucose-6-phosphatase activity in brain. The observations made by Sacks et al. [Neurochem. Res. 8, 661-685 (1983)] on which they based their criticisms of the deoxyglucose method have been examined and found to have no relationship to the conclusions drawn by them. (1) The observations o...

Underwood, P.C.; Adler, G.K., 2013: The renin angiotensin aldosterone system and insulin resistance in humans. Alterations in the renin angiotensin aldosterone system (RAAS) contribute to the underlying pathophysiology of insulin resistance in humans; however, individual differences in the treatment response of insulin resistance to RAAS blockade persist....