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Protein synthesis in Semliki Forest virus-infected cells is not controlled by permeability changes

, : Protein synthesis in Semliki Forest virus-infected cells is not controlled by permeability changes. Journal of General Virology 64: 2631-2640

The uptake of the GTP analogue guanylyl(beta,gamma-methylene)diphosphonate (GppCH2p) is the same in Semliki Forest virus (SFV)-infected BHK cells as in mock-infected cells, in spite of the fact that protein synthesis is inhibited by GppCH2p more markedly in SFV-infected cells than in control cells. A possible explanation for this difference is that infected cells have a lower concentration of GTP and a lower ratio of GTP:GDP than uninfected cells, and the analogue may thus be a more effective competitive inhibitor of translation. We conclude that in this system, the difference between infected and uninfected cells lies not at the plasma membrane but within the cytoplasm.


PMID: 6319551

DOI: 10.1099/0022-1317-64-12-2631

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