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Quantitative morphological analysis of the development of myocardial hypertrophy in spontaneously hypertensive rats


, : Quantitative morphological analysis of the development of myocardial hypertrophy in spontaneously hypertensive rats. Arkhiv Patologii 45(6): 26-35

Myocardium of normotensive Wistar rats and that of spontaneously hypertensive SHR rats aged 1, 4, and 11 months was studied using light and electron stereological techniques. The volume density of contractile apparatus and sarcoplasmic reticulum was shown to increase while that of the energy-producing compartment to decrease in heart hypertrophy. In the period of considerable hypertrophic growth of cardiomyocytes which coincided with the onset of hypertension the volume densities of capillaries and endothelial cells decreased. A secondary increase of the microcirculatory bed should be considered as a process of stabilization of the quantitative parenchymal-stromal ratios in myocardial hypertrophy.

US$29.90

PMID: 6226257


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