+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Real-time optical imaging of naturally evoked electrical activity in intact frog brain

, : Real-time optical imaging of naturally evoked electrical activity in intact frog brain. Nature 308(5962): 848-850

A major obstacle to understanding the function and development of the vertebrate brain is the difficulty in monitoring dynamic patterns of electrical activity in the millesecond time domain; this has limited investigations of such phenomena as modular organization of functional units, seizure activities and spreading depression. The use of voltage-sensitive dyes and the recent development of the use of an array of photodiodes has provided a unique technique for monitoring the dynamic patterns of electrical activity in real time from a variety of invertebrate or vertebrate neuronal preparations including the rat cortex. In the present study, this technique has been used to investigate the intact optic tectum of the frog. We demonstrate that optical measurements can be used for real-time imaging of spatio-temporal patterns of neuronal responses and for identification of functional units evoked by natural visual stimuli. We report also the structure of the new voltage-sensitive probe that facilitates the in vivo applications of this technique.


PMID: 6717577

Other references

Deden, C.M., 1987: Management of hedgehogs. Tijdschrift Voor Diergeneeskunde 112(3): 169-170

Barbut S., 1990: Effects of three chopping methods on bologna characteristics. Bologna containing 30% fat was prepared by using three commercially employed methods: 1) Build up method (BM), fat added to the pre-chopped lean meat, 2) Shock Method (SM), fat and lean meat chopped separately and only together at the very last st...

Gareen, I.; Morgenstern, H.; Greenland, S., 1997: Explaining the association between maternal age and risk of cesarean delivery. American Journal of Epidemiology 145(11 SUPPL ): S63

Dykstra, C.C.; Perfect, J.; Boykin, D.W.; Wilson, W.D.vid; Tidwell, R.R., 2000: Methods of combatting infectious diseases using dicationic bis-benzimidazoles. The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to tr...

Kealey, S.; Turner, E.M.; Husbands, S.M.; Salinas, C.A.; Jakobsen, S.; Tyacke, R.J.; Nutt, D.J.; Parker, C.A.; Gee, A.D., 2013: Imaging imidazoline-I2 binding sites in porcine brain using 11C-BU99008. Changes in the density of imidazoline-I<SUB>2</SUB> binding sites have been observed in a range of neurologic disorders including Alzheimer's disease, Huntington's chorea, and glial tumor; however, the precise function of the...

Rubinow, S.I., 1977: A suggested method for the resolution of Scatchard plots. Immunochemistry 14(8): 573-576

Abdulcader, M.H., 1964: The Clinical Manifestations Of Low-Grade Wuchereria Bancrofti Infection. Journal of Tropical Medicine and Hygiene 67: 72-74

Sperandio, G.; Venzi, L., 1990: A method for evaluating accounting packages in agriculture. Information technology for agriculture has been poorly developed so far in Italy; the competence of available programs is indicated. This paper presents a means of evaluating the available software. Ten attributes are required of packages, includi...

Duprez, D.; Bell, E.J.D.H.; Richardson, M.K.; Archer, C.W.; Wolpert, L.; Brickell, P.M.; Francis West, P.H., 1996: Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb. Bone morphogenetic proteins are members of the transforming growth factor beta (TGF-beta) superfamily which are involved in a range of developmental processes including modelling of the skeleton. We show here that Bmp-2 is expressed in mesenchyme...

Almeida, H.; Magalhães, M.; Magalhães, M.C., 1987: Nucleolar alterations induced by 4-aminopyrazolo(3,4-d)pyrimidine in adrenal cortex and liver cells of rat. The nucleolar ultrastructural changes produced in adrenal zona fasciculata cells and hepatocytes of rats by 4-aminopyrazolo(3,4-d) pyrimidine (4-APP), an inhibitor of the lipoprotein synthesis, are described. Male rats were injected intraperitonea...