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Role of surface-active phospholipids in gastric cytoprotection


, : Role of surface-active phospholipids in gastric cytoprotection. Science 219(4590): 1327-1329

Intragastric administration of a liposomal surfactant suspension markedly reduced acid-induced gastric ulcerogenesis and bleeding in rats. The concentration of surface-active molecules intrinsically present in the gastric mucosa was increased two to six times by administration of 16,16-dimethyl prostaglandin E2. Thus, local accumulation of surface-active phospholipids may be an integral component of the cytoprotective mechanism activated by prostaglandin treatment.

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PMID: 6828859


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