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Significance of lymphocyte migration in altering the zonal structure of the lymphoid organs of children with brain tumors

, : Significance of lymphocyte migration in altering the zonal structure of the lymphoid organs of children with brain tumors. Arkhiv Patologii 46(7): 26-32

It is known from the literature that the tumours of diencephalon and stem regions of the brain are complicated by hypothalamus-pituitary-adrenal deficiency; these patients show the disturbance of the humoral and cellular immunity as well. The results of morphological examination of central and peripheral organs of immunogenesis in children with the above tumours are presented. The adrenal atrophy resulting from the hypothalamus-pituitary deficiency is described. The basis of the lymphoid organs alteration is their hyperplasia. The lymphoid organs weight is increased due to lymphocyte proliferation of the thymus lobules cortex and B-dependent zones of the spleen, lymph nodes. The operation results in the release of the adrenal cortex hormones into circulation and massive lymphocyte destruction in the B-dependent zones of lymphoid organs. Lymphocytes from the thymus migrate through the circulation to the T-zones of peripheral lymphoid organs with the resulting alteration of their zonal structure.


PMID: 6477171

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