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Studies on the mechanism of action of nerve growth factor


, : Studies on the mechanism of action of nerve growth factor. Proceedings of the National Academy of Sciences of the United States of America 69(8): 2268-2272

In this study, explanted chick-embryo sensory ganglia were treated with nerve growth factor, and cellular concentrations of neurotubule protein were measured chemically by a colchicine-binding assay. Even after brief time periods, ganglia treated with growth factor were enriched in neurotubule protein, as compared with untreated (control) ganglia. Furthermore, studies with ganglia treated with both vincristine and growth factor demonstrated that neurotubule protein synthesis can occur even though neurite outgrowth is abolished. Several lines of evidence indicate that the growth factor stimulates de novo synthesis of neurotubule subunit protein, and that this effect precedes neurite extension. Like nerve growth factor, dibutyryl cyclic AMP also stimulates neurite outgrowth from embryonic sensory ganglia, yet it does not increase neurotubule protein levels. Available information suggests that the ability of growth factor to elicit rapid neurite outgrowth is closely related to its ability to increase cellular neurotubule levels. Cyclic AMP appears to stimulate neurite outgrowth by a different mechanism.

US$19.90

PMID: 4340752

DOI: 10.2307/61520


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Vainshtein, T.A., 1953: Remote results of tonsillectomy. Vestnik Otorinolaringologii 15(4): 51-52

Yang, C-Ching., 2016: Characterization of Scattered X-Ray Photons in Dental Cone-Beam Computed Tomography. Scatter is a very important artifact causing factor in dental cone-beam CT (CBCT), which has a major influence on the detectability of details within images. This work aimed to improve the image quality of dental CBCT through scatter correction. S...

Krauss, G.L.; Serratosa, J.M.; Villanueva, V.; Endziniene, M.; Hong, Z.; French, J.; Yang, H.; Squillacote, D.; Edwards, H.B.; Zhu, J.; Laurenza, A., 2012: Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures. To evaluate the efficacy and safety of perampanel 2, 4, and 8 mg/day added to 1-3 concomitant antiepileptic drugs (AEDs) in patients with uncontrolled partial-onset seizures. During this double-blind, placebo-controlled trial, patients with persis...

Fuertes-Polo, C., 1979: Study on the transmission of exocortis. I. Mechanical transmission from shield field plant to the greenhouse plant citron Etrog 861. Anales Instituto Nacional de Investigaciones Agrarias Serie proteccion vegetal: 0) 25-31

Schutz, Y.; Jéquier, E., 1986: Energy expenditure. A letter to the editor compares the use of the ratio of 24-hour energy expenditure (EE) to basal metabolic rate (BMR) for expressing the relative magnitude of EE in obese subjects between the EE/BMR value of a previously reported study under free-...

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Maltin, C.A.; Delday, M.I.; Hay, S.M., 1990: The effect of clenbuterol administration in utero and throughout lactation on pre- and post-natal muscle development in the rat. The beta -adrenergic agonist, clenbuterol 2 mg/kg diet was fed to pregnant rats during gestation and throughout lactation. Clenbuterol did not affect mean foetal number, but mean foetal body weight was significantly reduced. Heart weights were inc...

Nishimura, H.; Kiyozuka, Y.; Imamura, K.; Ohkura, N.; Murakami, F.; Yakushiji, M., 1997: Relation between CA125 levels and second-look operation for ovarian cancer. We investigated the relationship between the serum level of CA125 before a second-look operation (SLO) and SLO findings in 196 patients with adenocarcinoma of the ovary. SLO findings were positive in 38 (19.4%) of 196 patients. The positive rate t...

Reber, H.A.; Widdison, A.L., 1994: Pathogenesis of infected pancreatic necrosis. Bradley, E L , III [Editor] Acute pancreatitis: Diagnosis and therapy 85-92

Boer, Ah-De, 1984: Hydrostatic pressure applied to roots: its effect on respiration and trans-root electrical potential. Membrane transport in plants: proceedings of the symposium held in Prague Czechoslovakia August 15-21-1983 editors WJ Cram et al: 156