+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Synthesis of 1-aroyl-4H(R)-thiosemicarbazides, the corresponding 5-aryl 4H(R)-1,2,4-triazolin-3-thiones and some derivatives of pharmaceutical interest

, : Synthesis of 1-aroyl-4H(R)-thiosemicarbazides, the corresponding 5-aryl 4H(R)-1,2,4-triazolin-3-thiones and some derivatives of pharmaceutical interest. Il Farmaco; Edizione Scientifica 36(3): 181-196

A series of 1-aroyl-4H(R)-thiosemicarbazides (IV-XVIII) and the corresponding 5-phenyl-4H(R)-1,2,4-triazolin-3-thiones (XIX-XXXIII) were synthesized: biological assay demonstrated their in vitro antibacterial and antimycotic activities. The preparation of same hydrazinoaroylthiazoles (XXXIV-XXXVI) was reported also, obtained by condensation of 1-aroyl-4H-thiosemicarbazides with phenacyl bromide and the synthesis of thiazole[3,2-b]-s-triazol-3(2H)-ones (XLIX-LI) prepared by cyclodehydration of carboxymethylthiotriazoles (XLVI-XLVIII). The results of pharmacological testing for both series of derivatives (XLIX-LI) and (XLVI-XLVIII) showed good antiinflammatory and antipyretic activities.


PMID: 7227504

Other references

Delbanco, T.; Sands, D.Z., 2004: Electrons in flight--e-mail between doctors and patients. New England Journal of Medicine 350(17): 1705-1707

Sastry, C.S.P.; Naidu, P.Y., 1998: Determination of pentoxifylline in pharmaceutical formulations using iodine as oxidizing agent. Simple, selective and sensitive spectrophotometric methods are described for the determination of pentoxifylline, based on the haloform reaction with a known and excess of standard iodine solution under alkaline conditions. The excess of iodine is...

McCarthy, D.M., 1981: Peptic ulcer heterogeneity and clinical implications. Annals of Internal Medicine 95(4): 507-508

Kirkis, I.I.; Jasnova, L.N.; Urghenko, A.W., 1967: The mutagenic effect of the extracts from irradiated mammalian tissues. Unknown

Melles, 1957: Control of tufted hair grass. Rasenschmiele [Deschampsia caespitosal may be controlled by spot treatment with 2% sodium chlorate; however, lateral leaching may injure adjacent desirable grasses; therefore, it is recommended that a 1:4 mixture of sodium chlorate and kainite be...

V.V.Zolotuhin, R.V.Efimov, V.V.Anikin, A.G.Demin, M.V.Knushevitskaya, 2012: Changes in the suprageneric classification of Lasiocampidae Lepidoptera based on the nucleotide sequence of gene EF-1?. The nucleotide sequences of nuclear gene EF-1? were determined for 49 species of Lasiocampidae from Eurasia and Africa. Based on these data, the phylogeny of the family was reconstructed using the minimum evolution, maximum parsimony, maximum like...

Marten, G.G., 2007: Turtles. Juvenile turtles have the capacity to eat more than 500 3rd and 4th instar mosquitos per day. Keeping one turtle in each water-storage tank during field trials for a dengue-control project in Honduras eliminated all mosquito production from the ta...

Wang, Z.; Kang, S.; Jensen, C.R.; Liu, F., 2012: Alternate partial root-zone irrigation reduces bundle-sheath cell leakage to CO2 and enhances photosynthetic capacity in maize leaves. The physiological basis for the advantage of alternate partial root-zone irrigation (PRI) over common deficit irrigation (DI) in improving crop water use efficiency (WUE) remains largely elusive. Here leaf gas exchange characteristics and photosyn...

Cianchi, R.; Urbanelli, S.; Villani, F.; Sabatini, A.; Bullini, L., 1985: Electrophoretic studies in mosquitoes: recent advances. Recent findings are discussed on the electrophoretic approach to genetic variability in mosquitoes, on detection and study of sibling species, on comparison of gene and chromosome divergence and on the speciation processes in complexes of sibling...

Sebens K.P.; Lewis J.R., 1985: Rare events and population structure of the barnacle semibalanus cariosus. Populations of the large interidal barnacle S. cariosus (Pallas, 1788) in the San Juan Islands, Washington [USA] were dominated by small (2-9 mm diameter) individuals, but there was often a distinct peak of large barnacles (.gtoreq. 20 mm) in the...