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T cell responses to BPV-4 E7 during infection and mapping of T cell epitopes

, : T cell responses to BPV-4 E7 during infection and mapping of T cell epitopes. Virology 206(1): 504-510

Vaccination of cattle with the recombinant E7 protein of bovine papillomavirus type 4 (BPV-4) prior to BPV-4 infection has been shown to retard development of papillomas and accelerate their regression. To understand the mechanism of regression we have measured proliferation of peripheral blood mononuclear cells (PBM) to E7 in vitro during the course of BPV-4 infection in both vaccinated and nonvaccinated cattle. In vaccinated cattle, T cells specific for E7 could be detected at high levels shortly after challenge, whereas in nonvaccinated cattle low responses of E7-specific T cells could be detected in only a few animals at the late stages of papilloma development. Using short overlapping synthetic peptides corresponding to the E7 protein, three T cell epitopes have been identified. T1 (aa 31-59) was immunodominant and T2 (aa 70-88) and T3 (aa21-40) were minor epitopes.


PMID: 7530395

Other references

Buechi J.; Perlia X.; Tinani M., 1971: Relationships between physicochemical properties penetration into mono molecular lipoid films and the action of cinchocaine and some local anesthetics part 28. Arzneimittel-Forschung 21(12): 2074-2089

Assing, V., 2007: On the genus Pseudobium Mulsant & Ray II. A new species from Pakistan and additional records (Insecta: Coleoptera: Staphylinidae: Paederinae). Pseudobium pakistanicum nov. sp. (NW-Pakistan) is described and illustrated. Additional records of Pseudobium species from the Western Palaearctic region are presented, among them first country records from Iran (2), Turkey (1), Algeria (1), and A...

D.Lautour, G., 1960: A leaf squash technique for chromosome studies in grasses. A satisfactory leaf squash technique has been developed for chromosome studies in grasses. Leaf buds, dissected from actively growing young tillers, were pre-treated in solutions of colchicine or other spindle inhibitors. After fixation, portions...

Fechner, G.G.; Sivaloganathan, S., 1987: Demonstration of myocardial infarction in putrefying bodies. Journal of Clinical Pathology 40(8): 922-924

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Horácek, Jír.; Laukkanen, A-Maria.; Sidlof, P., 2007: Estimation of impact stress using an aeroelastic model of voice production. The maximum impact stress at the contact of the vocal folds achieved during the oscillation cycle was estimated in phonation using an aeroelastic model of voice production. Relations of impact stress to the lung pressure, fundamental frequency of...

Njølstad, I., 1995: Cardiovascular examination of 40-year-old subjects in Hordaland. Tidsskrift for den Norske Laegeforening 115(2): 270-271

Denton, D.A., 1957: A gregarious factor in the natural conditioned salivary reflexes of sheep. Nature 179(4555): 341-344

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Lynn, W.S.; Brown, R.H.; Perryman, N.C.; Weber, C., 1958: The effects of cholesterol-feeding in rabbits. The following observations have been made on cholesterol-fed rabbits: Factors which inhibit the removal of cholesterol from blood, in vivo are: (1) an increase in glucose ingestion, (2) an increased fat intake, either saturated or unsaturated, and...