+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The effect of low dose Ara-C in acute nonlymphoblastic leukaemias and atypical leukaemia

, : The effect of low dose Ara-C in acute nonlymphoblastic leukaemias and atypical leukaemia. British Journal of Haematology 58(1): 9-18

Nine patients with nonlymphocytic leukaemia and one patient with refractory anaemia with excess of blasts (RAEB) were treated subcutaneously with Ara-C at a low dose of 10 mg/m2/12 h; complete remission was obtained in seven patients. In all cases severe pancytopenia was observed during treatment. We measured the concentration of Ara-C in serum, and found that the maximum concentration reached a peak (52-132 ng/ml; mean 84.2 ng/ml) at 15 min following injection. These concentrations can be considered sufficient to inhibit DNA synthesis. Primary short-term culture of human leukaemic cells with low dose Ara-C was also performed, and differentiation of leukaemic cells was observed for several types of leukaemic cells. The in vitro findings corresponded to the observed clinical effects. From the above results, the action of low dose Ara-C may have resulted from a combination of two different mechanisms, its cytostatic effect and its differentiation-inducing effect.


PMID: 6466575

Other references

dos Santos, A.Angelini.; Mansano-Schlosser, T.Cristina.dos.Santos.; Ceolim, M.Filomena.; lost Pavarini, S.Cristina., 2014: Sleep, fragility and cognition: a multicenter study with Brazilian elderly. This study aimed to analyze the joint influence of background variables (age, gender, and income), weakness and sleep disorders on cognition in elderly community residents. This is an excerpt from the multicenter project Frailty in Elderly Brazili...

Johnson, S.; Gilmore, C.; Gallimore, I.; Jaekel, J.; Wolke, D., 2015: The long-term consequences of preterm birth: what do teachers know?. The knowledge and information needs of education professionals were assessed to determine how prepared they feel to support the growing number of preterm children entering schools today. In a national survey, 585 teachers and 212 educational psych...

Balligand, J.L.; Godfraind, T., 1994: Effect of nisoldipine on contractions evoked by endothelin-1 in human isolated distal and proximal coronary arteries and veins. We investigated the differences in the vasoconstrictor effect of endothelin-1 (ET-1) on small and large human coronary arteries and veins and blockade of ET's action with calcium antagonists. Rings from distal and proximal human coronary arte...

Gill, TS.; Pande, J.; Tewari, H., 1991: Effects of endosulfan on the blood and organ chemistry of freshwater fish, Barbus conchonius Hamilton. Prolonged exposure (4 weeks) to 6.72 ppb of the organochlorine insecticide endosulfan induced disturbances in the blood and organ chemistry values of a common fish, Barbus conchonius. In blood the total lipids, cholesterol, and proteins were decre...

Tay, Y.K.; Weston, W.L.; Aeling, J.L., 1996: Reactive perforating collagenosis in Treacher Collins syndrome. Journal of the American Academy of Dermatology 35(6): 982-983

Milkovich Sarah M.; Plaut J.J., 2007: Martian south polar layered deposit stratigraphy and implications for accumulation history. Abstracts of Papers Submitted to the Lunar and Planetary Science Conference 38: (Abstract 1929

Pianezza, M.L.; Mokhtassi, A.; Wu, L.; D'A Honey, R.John., 2006: Case report: renal lymphangiectasia. Renal lymphangiectasia is a rare renal condition. We present a case of bilateral renal lymphangiectasia in a 52-year-old man who presented with bilateral flank pain and gross hematuria. The clinical features, diagnosis and characteristic imaging f...

Koncicki, A.; Krasnodebska Depta, A.; Zdunczyk, Z.; Jankowski, J.; Szarek, J.; Mazur Gonkowska, B.; Guiro, S., 2001: Influence of feed mixtures with differentiated degree of fat oxidation degree on haemorrhagic enteritis virus (HEV) in turkeys. The effects of feed mixtures with different degree of fat oxidation on HEV infection were studied in turkeys. Turkeys were fed on feed mixtures with rape oil and poultry fats of different degrees of oxidation. Turkeys in groups I-IV, aged 6 weeks,...

Labombardi, V.J.; Cataldo Caputzal, L.; Mayer, F., 1995: Cost effective determination of E coli bacteriuria utilizing a MacConkey-MUG/ modified CLED Urine dipslide. Abstracts of the General Meeting of the American Society for Microbiology 95(0): 67

He, S-Heng.; Xie, H., 2004: Modulation of histamine release from human colon mast cells by protease inhibitors. To investigate the ability of protease inhibitors to modulate histamine release from human colon mast cells. Enzymatically dispersed cells from human colon were challenged with anti-IgE or calcium ionophore A23187 in the absence or presence of try...