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The influence of hypertension on injury-induced myointimal thickening


, : The influence of hypertension on injury-induced myointimal thickening. Surgery 88(2): 254-259

Although hypertension has been identified as a risk factor in atherosclerosis, how hypertension enhances plaque growth is not clear. To study the influence of essential hypertension on injury-induced arterial intimal thickening, we employed a model of arterial endothelial injury (aortic balloon injury) in spontaneously hypertensive rats (SHR). SHR rendered normotensive with drugs served as controls. The injured vessels were fixed by perfusion at intervals between 2 weeks and 3 months and studied by light, transmission, and scanning electron microscopy. Endothelial regeneration at 2 weeks was assessed by the difference between total and blue-stained arterial surface area in rats receiving Evans blue by injection and was decreased in SHR. Intimal thickening was increased in SHR as compared with controls at all time intervals and appeared to be due to increased smooth muscle cell proliferation. Although neither SHR or controls injured arteries were stained by Evans blue at 3 months, the SHR (but not the control) injured arteries demonstrated subendothelial edema and focal necrosis in the intima. These data in a model of arterial endothelial injury support the concept that essential hypertension has a deleterious effect on arterial wound healing by enhancing arterial myointimal thickening. This effect can be reduced by adequate control of the hypertension with drugs.

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PMID: 7394706


Other references

Rogers J.; Waldron T., 1989: The enthesis in paleopathology. American Journal of Physical Anthropology 78(2): 292

Gregory, R.J., 1997: The limits to health care and rehabilitation. Customary in the field of health care and rehabilitation, a spirit of optimism pervades the work and attitudes held by most practitioners. Professionals have many reasons and excellent track records in working with individual clients to support op...

Idler D.R., 1985: The relationship of some steroid hormones and their glucuronides to the terminal stages of oocyte maturation in landlocked atlantic salmon. American Zoologist: 69a

Janda R.; Conklin J.; Mitros F., 1989: An outbreak of chronic diarrhea associated with contaminated water characterized by multifocal colitis. Gastroenterology 96(5 PART 2): A235

Weldon, R.A.; Erdie, C.R.; Oliver, M.G.; Wills, J.W., 1990: Incorporation of chimeric gag protein into retroviral particles. The product of the Rous sarcoma virus (RSV) gag gene, Pr76gag, is a polyprotein precursor which is cleaved by the viral protease to yield the major structural proteins of the virion during particle assembly in avian host cells. We have recently sh...

Anonymous, 1991: High-tech carp go outdoors. San Francisco chronicle: 3, A17

Shieh, S-Jia.; Chou, F-Cheng.; Yu, P-Ning.; Lin, W-Chi.; Chang, D-Ming.; Roffler, S.R.; Sytwu, H-Kang., 2009: Transgenic expression of single-chain anti-CTLA-4 Fv on beta cells protects nonobese diabetic mice from autoimmune diabetes. T cell-mediated immunodestruction of pancreatic beta cells is the key process responsible for both the development of autoimmune diabetes and the induction of rejection during islet transplantation. In this study, we investigate the hypothesis tha...

Yen, E.; Lin, S.; Chen, H.-Yen; Chao, L.; Huang, B.-Shouh; Liang, W.-Tzong, 2010: E-Science on earthquake disaster mitigation by EUAsiaGrid. Geophysical Research Abstracts 12

Killeen, R.; McNeill, G.; Torreggiani, W., 2010: Re-appearance of an ilio-ilio arteriovenous fistula after endovascular stent grafting demonstrated on MDCT. Jbr-Btr 93(1): 33-33

Omland, G., 1955: Cases of acute intoxication. Nordisk Medicin 53(4): 153-157