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The use and potential of bone marrow allograft and whole-body irradiation in the treatment of leukemia

, : The use and potential of bone marrow allograft and whole-body irradiation in the treatment of leukemia. Cancer 50(8): 1449-1454

A brief history of the clinical application of marrow transplantation based on knowledge gained from ten years work utilizing the dog as an animal model is summarized. The techniques for marrow transplantation, donor selection, and conditioning of the recipient are described. Thirteen of the first 110 endstage leukemic patients who received allogeneic grafts and six of 16 patients who received syngeneic grafts are alive 6-11 years after grafting. Encouraged by the apparent "cure" of leukemia in these poor-risk patients, the Seattle transplant group in 1976 decided to give patients transplants earlier in the course of their disease. Patients with acute lymphoblastic leukemia in second or subsequent relapse were considered to have a poor prognosis. Twenty-two such patients received transplants, with seven surviving in remission 3-5 years later. Nineteen patients with acute nonlymphoblastic leukemia received transplants in first remission and 11 are living in remission 3.5-5.5 years after grafting. The median survival will not be less than 42 months. The problems associated with graft-versus-host disease and recurrence of leukemia and methods aimed at eliminating these problems are discussed.


PMID: 6749274

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Endo, Yutaka; Takahashi, Hiroshi; Kirihara, Kazutaka; Kaminaga, Norhiro; Fujita, Rikiya, 1998: Endoscopic three dimensional topological image analysis using sequentially recorded images. We have employed a new endoscopic topological image analyzing system in collaboration with the Imaging Science and Engineering Laboratory, the Tokyo Institute of Technology and the Olympus Optical Co. Ltd. The system consists of an ordinary video...

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Grieco, M.H.; Pierson, R.N., 1970: Cardiopulmonary effects of methacholine in asthmatic and normal subjects. Journal of Allergy 45(4): 195-207

Reilly, J.; Bischoff, J., 2008: Remote monitoring tested. Provider 34(9): 57, 59-60

Anonymous, 1981: The properties of Sarawak timber. Red Selangan (heavy Shorea spp.). Brief notes about the wood of Shorea spp. (mainly S. guiso and S. kunstleri) including: wood characteristics; seasoning properties; natural durability and preservation; working qualities; physical and mechanical properties; and uses.

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Zamora L.L.; Garcia Mateo J.V.; Martinez Calatayud J., 1992: Entrapment of reagents in polymeric materials indirect atomic absorption spectrometric determination of isoniazid by oxidation with manganese dioxide incorporated in polyester resin beads in a flow injection system. A method for entrapment of reagents is described. The experimental procedure is based on the dispersion of the reagent (MnO2) into an unsaturated polyester solution and grinding the product to give the required particle size (300-400 .mu.m). The r...

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Kruger, G.; Eloff, J.; Pretorius, J., 1981: Morphological changes in toxic and non-toxic microcystis isolates at different irradiance levels. Journal of phycology 17(1): 52-56

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