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Topical and systemic glucocorticoid potencies of budesonide and beclomethasone dipropionate in man


, : Topical and systemic glucocorticoid potencies of budesonide and beclomethasone dipropionate in man. European Journal of Clinical Pharmacology 22(6): 523-529

Topical anti-inflammatory (cutaneous "vasoconstriction") and systemic glucocorticoid (depression of plasma cortisol and changes in differential WBC count) potencies of the two glucocorticoids budesonide and beclomethasone dipropionate (BDP) were compared in human volunteers. After topical application, budesonide was 2-3 times more potent than BDP in inducing "vasoconstriction". After oral administration, on the other hand, budesonide was 2-4 times less potent than BDP in depressing plasma cortisol and changing the total or differential WBC. After inhalation, too, significant differences in favour of budesonide were noted, but the divergence between the drugs was less pronounced. The improved relationship between the topical and systemic glucocorticoid effects of budesonide makes it a promising alternative for aerosol treatment in asthma.

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PMID: 7128664


Other references

Guyton, A.C., 1948: Relation of symptoms to the pathological physiology in poliomyelitis. Journal of the Tennessee State Medical Association. Tennessee State Medical Association 41(7): 254-258

Tosun, F.; Akyurek, A.; Ross, J.G., 1968: Performance of midwest winter wheats in Eastern. Eleven varieties of hard red winter wheat from the American midwest and two Turkish soft winter wheats were tested. American varieties remained upright but the native varieties were susceptible to lodging. The best American varieties gave yields e...

Stonehouse, J., 1994: Assessment of Andean bean diseases using visual keys. Pictorial keys are given for the visual assessment of damage to bean (Phaseolus vulgaris) leaves of diseases found in the Colombian Andes. There are keys for anthracnose, rust, ascochyta blight, web blight and angular leaf spot, and also for necro...

Tomlinson, G.A.; Jahnke, L.L.; Hochstein, L.I.; Jahnke, L.L.; Hochstein, L.I., 1986: Halobacterium denitrificans sp. nov., an extremely halophilic denitrifying bacterium. Halobacterium denitrificans was one of several carbohydrate-utilizing, denitrifying, extremely halophilic bacteria isolated by anaerobic enrichment in the presence of nitrate. Anaerobic growth took place only when nitrate (or nitrite) was present...

Li, Z-Hui.; Wang, J.; Cai, R-Lin.; Wang, Y-Wen.; Hu, J-Peng., 2013: Establishment and evaluation of a rat model of ulcerative colitis with syndrome of dampness stagnancy due to spleen deficiency. To establish a rat model of ulcerative colitis with syndrome of spleen deficiency and dampness stagnancy. Sixty rats were divided into normal control group, ulcerative colitis group, ulcerative colitis with syndrome of spleen deficiency and dampne...

Clark L.W.; Emory S.E., 1972: The bromination of beta keto acids as an intermediate step in the amination of acetic acids and the alkylation of amines. Journal of the Elisha Mitchell Scientific Society 88(4): 193

Meloni G.A.; Palu G.; Valisena S., 1990: Sporadic and intrinsic macrolide resistance in mollicutes. Zentralblatt fuer Bakteriologie Supplement 20: 103-110

Bhatia, R.P.; Lordi, N.G., 1979: Electrical conductance of directly compressible materials under pressure. An electrometer that allowed direct recording of resistance changes during compression was used to measure the conductances of sodium chloride, potassium chloride, ammonium chloride, and sodium citrate. The effects of initial particle size, lubric...

Müller, R.; Willers, H.; Freise, J.; Höpken, W., 1978: Chronic hepatitis as sequela of acute viral hepatitis A and hepatitis non A - non B. 329 patients with acute ouvert viral hepatitis which occurred in the Hannover area 1975 were classified according to virological data. The proportions of type A and type non A - non B hepatitis were each approximately 20 percent of the total cases...

Elmore, H.; Whittier, D., 1973: The role of ethylene in the induction of apogamous buds in Pteridium aquilinum gametophytes. Planta 11 (1) 85-90