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Urinary secretory immunoglobulin A and free secretory component in pyelonephritis


, : Urinary secretory immunoglobulin A and free secretory component in pyelonephritis. American Journal of Kidney Diseases 26(4): 590-594

The immune defense mechanisms of mucosal surfaces involve secretory immunoglobulin A (sIgA) antibodies and, to a lesser degree, other specific and nonspecific immune factors. These antibodies are dependent on a secretory component (SC) for their transmission through the epithelium. This SC is also secreted without Ig as free SC (FSC). The kidney does produce these proteins; however, the ability of the lower urinary tract to secrete them has not been shown. Thus, an upper urinary tract infection should produce more urinary sIg and possibly more FSC than a lower tract infection. To demonstrate this, urine was obtained from normal controls (N = 33), cystitis patients (N = 22), and pyelonephritis patients (N = 27). Monoclonal antibodies binding to specific conformational epitopes were used in an enzyme-linked immunosorbent assay to detect the levels of sIgA and FSC in these groups. Previous sIgA measurements have been hampered by lack of specificity of the capture antibody. Urine creatinine was obtained to correct for the effect of diuresis. A one-tailed Student's t-test for nonparametric populations was performed to assess differences. The sIgA levels in the normal and cystitis groups were equivalent (1.4 micrograms/mg/mL and 1.3 micrograms/mg/mL, respectively; P = 0.32). When these two groups were compared with the pyelonephritis group (24.1 micrograms/mg/mL), a statistically significant difference was seen (P = 0.012 and P = 0.011, respectively), with no overlap. There was a statistical difference in the levels of FSC in these same groups, but a large degree of overlap.

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PMID: 7573012


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Bhattacharyya, N.K., 1988: Reproductive factors affecting meat production. A review of mainly Indian work on goats. Poor nutrition, management and disease increase the age at sexual maturity and the kidding interval. Reproductive disorders can be divided into occasional uterine infections, early embryonic losses, and lat...

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Nefzi, A.; Kirsch, J.M.; Baux, S., 1988: Treatment of graft donor sites with a sodium carboxymethylcellulose dressing. The treatment of donor sites of grafts used to cover skin defects is very diversified, but the objective of reducing pain, obtaining healing as rapidly as possible and reducing the anesthetic impairment is always the same. The authors have tested...

Hope, R.R.; Sherlag, B.J.; Lazzara, R., 1980: Excitation of ischemic myo cardium altered properties of conduction refractoriness and excitability. Reentrant ventricular arrhythmias arise in variable epicardium overlying the transmural infarction zone in the dog 3-9 days after left anterior descending coronary artery ligation. Effects of pacing (90-360 beats/min) from the epicardium in the no...

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Gorlatova, N.V.; Kryukova, E.G., 1994: The effect of oversynthesis cloned gene products on methanol metabolism in recombinant methylotrophic yeast Hansenula polymorpha. As is shown expression homologous (dihydroxyacetone kinase) and heterologous (HBsAg, beta-galactosidase) genes in methylotophic yeasts Hansenula polymorpha DL1 negatively affects on the growth parameters of a host strain. The reducing of specific...

Sorvari, H.; Soininen, H.; Pitkänen, A., 1996: Calretinin-immunoreactive cells and fibers in the human amygdaloid complex. Calretinin is a calcium-binding protein that colocalizes with GABA in the cerebral cortex and hippocampus of the rat and the monkey. In the present study, we investigated the distribution of calretinin-immunoreactive cells and fibers in the human...

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