geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Vasopressin release by D-aspartic acid, morphine and prolyl-leucyl-glycinamide (PLG) in DI Brattleboro rats


, : Vasopressin release by D-aspartic acid, morphine and prolyl-leucyl-glycinamide (PLG) in DI Brattleboro rats. Pharmacology, Biochemistry, and Behavior 20(4): 519-525

The L-asparaginase activities of the brains of the Wistar, heterozygous and homozygous Brattleboro rats divided into three parts namely the anterior, middle and posterior which respectively contained cerebral cortex, hippocampus + midbrain + thalamus + hypothalamus cerebellum + pons + medulla oblongata were estimated. The L-asparaginase activities of all the three parts in the homozygous Brattleboro rats were significantly higher than in the Wistar rats as well as in the heterozygous Brattleboro rats. Twenty min following the injections of 200 mg/kg D-aspartic acid, 20 mg/kg morphine, 200 mg/kg D-aspartic acid + 20 mg/kg morphine, 6 mg/kg prolyl-leucyl-glycinamide (PLG) and 6 mg/kg PLG + 20 mg/kg morphine the L-asparaginase activities of all three parts of the homozygous Brattleboro rat brains were found to be significantly inhibited. After having seen the suppressive effect of the drugs and their combinations used before the homozygous Brattleboro rats were given D-aspartic acid, morphine, D-aspartic acid + morphine, PLG and PLG + morphine for seven days. Then their plasma vasopressin levels were determined by RIA. The treatments applied to the homozygous Brattleboro rats caused the appearance of a significant amount vasopressin in the plasma. The results were interpreted as evidence for the fact that the inhibition of the brain L-asparaginase provides and/or accelerates the biosynthesis and/or release of vasopressin. As morphine has a vasopressin releasing and a brain L-asparaginase inhibiting effect the antidiuretic action of morphine was considered to be linked to its inhibitory effect on the brain L-asparaginase.

US$29.90

PMID: 6145163


Other references

Cuttell Jeffrey C.; Ivanovich Miro; Tellam John H.; Lloyd John W., 1988: Uranium-series isotopes in the groundwater of the Permo-Triassic sandstone aquifer, Lower Mersey Basin, U.K. Applied Geochemistry 3(3): 255-271

Gartin, Sa, 1985: Rich sources of inspriation. Agricultural education magazine 57(11): 4-5

Welander, U.; Henrysson, T.; Welander, T., 1997: Nitrification of landfill leachate using suspended-carrier biofilm technology. The possibility of nitrifying municipal landfill leachate using suspended-carrier biofilm technology was studied in three laboratory-scale reactors filled with three different types of carrier media. The effects of the temperature and the hydrauli...

Fukushima, H.; Nishimoto, J.; Okada, S., 1990: Sequencing and expression of a full-length cDNA for human alpha-L-fucosidase. Journal of Inherited Metabolic Disease 13(5): 761-765

Schermer, B.; Foust, L., 1997: Assumption of risk: federal regulation of physician incentive plans. Journal of Health and Hospital Law 30(1): 1-10

Prasad, A.S., 2001: Recognition of zinc-deficiency syndrome. Nutrition 17(1): 67-69

D.K.k, J.B.; Van Balken, M.R.; Roelofs, R.W.; Van Aarssen, Y.A.; Swinkels, D.W.; Gunnewiek, J.M.K.ein, 2002: Quantification of hTERT mRNA and telomerase activity in urine and bladder washings of patients with recurrent urothelial cell carcinomas. Acta Cytologica 46(1 Supplement): 160, January-February

Maemura, T.; Ogawa, K.; Shin, M.; Mochizuki, H.; Vacanti, J.P., 2004: Assessment of tissue-engineered stomach derived from isolated epithelium organoid units. Objective. Isolated stomach epithelial organoid units developed on biodegradable polymers were transplanted to assess the feasibility of a tissue-engineered stomach. Background. Despite recent advances in reconstruction techniques, total gastrecto...

Viswanathan, V.; Zhu, Y.; Bala, K.; Dunn, S.; Snehalatha, C.; Ramachandran, A.; Jayaraman, M.; Sharma, K., 2002: Association between ACE gene polymorphism and diabetic nephropathy in South Indian patients. To study the association of ACE gene polymorphism and diabetic nephropathy in South Indian subjects. Outpatient clinic of a specialized hospital. The study included 109 South Indian type 2 diabetic patients (72 males and 37 females; age 56.7 plus/...

Oliveira, D.B., 1997: Poststreptococcal glomerulonephritis: getting to know an old enemy. Clinical and Experimental Immunology 107(1): 8-10