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Vertebral abnormalities associated with synthetic retinoid use


, : Vertebral abnormalities associated with synthetic retinoid use. Journal of the American Academy of Dermatology 10(5 Pt 1): 817-823

Frequent symptoms of back and neck stiffness led to a radiographic investigation of the vertebral spine in patients receiving synthetic retinoids, isotretinoin and etretinate. X-ray examination of fifty patients with various skin disorders who received retinoids for at least 2 years were compared with seventy-two age- and sex-matched untreated patients. Differences in frequencies of defined abnormalities, which included anterior spinal ligament calcification and presence of osteophyte at two or more vertebral levels in the absence of joint space narrowing, were determined for treated and untreated patients. When the entire group of treated patients was compared with the entire group of those untreated, no statistically significant differences were observed. When only patients with basal cell nevus syndrome ( BCNS ) or basal cell carcinoma (BCC) who had never received retinoid were compared with those who received isotretinoin, the frequency of the defined abnormalities was significantly higher in the treated group (P less than 0.01). This study suggests that the ingestion of isotretinoin at mean total dose of 150,060 mg for an average of 2.9 years is associated with a statistically significant increase in developing an associated ossifying diathesis in patients with BCNS or BCC, when compared with matched, untreated controls.

US$29.90

PMID: 6586753


Other references

Mikhailovskaya E.V., 1986: Criteria for the evaluation of the phenomenon of emperipolesis in cytological studies. "Emperipolesis" phenomenon whose morphological expression is the formation of " a cell in a cell" complexes is regarded as one of the mechanisms participating in realization of interactions between stromal and hemopoietic cells...

Aeschimann, D., 1983: Silene vulgaris s.1. (Caryophyllaceae), evolution towards a weed. Candollea 8(2): 575-617

Langer, M.; Haeusler, E.A., 2010: Ventilator associated pneumonia (VAP): an impossible diagnosis? Call for a pragmatic approach. Many years after the introduction of the protected specimen brush (PSB) by Wimberley et al. as a tool to diagnose ventilator associated pneumonia (VAP), new sampling techniques have increased the controversy concerning the diagnosis of VAP. Agreem...

Danilov, Y.P.; Ver Hoeve, J.N.; Kim, C.B.Y.; Spear, P.D., 1999: Gender differences in transient PERG and VEP in anesthetized young adult rhesus monkeys. IOVS 40(4): S824, March 15

Naqvi, I.; Murtaza, M.; Nazir, M.Ressam.; Naqvi, H.Ali., 2011: Gender difference in age at onset of schizophrenia: a cross sectional study from Pakistan. To validate the effect of gender on age at onset of schizophrenia in a developing country. Medical records of 252 patients diagnosed with schizophrenia according to DSM-IV criteria at a tertiary care hospital in Karachi, Pakistan between 2002 and...

Wendland, G.; Kleinknecht, W., 1943: Keeping qualities of dried egg in an atmosphere of carbon dioxide. Spray-dried egg powder was stored in air or CO2at 3 degrees C. or room temperature for 6 months. Changes in appearance, solubility and flavour were followed and estimations of free fatty acids and loosely bound ammonia were made. Gas packing marke...

Langford, R.W., 1981: Teenagers and obesity. Two traditional weight reduction treatments, decreased caloric intake and increased caloric output, are not very effective in treating obese teenagers. Peer support and physical activity could be important factors in achieving weight loss. A small...

Wei, P.; Sun, E.C.; Liu, N.H.; Yang, T.; Xu, Q.Y.; Zhao, J.; Qin, Y.L.; Feng, Y.F.; Li, J.P.; Wang, W.S.; Zhang, C.Y.; Wu, D.L., 2013: Identification of a novel bluetongue virus 1-specific B-cell epitope using a monoclonal antibody against the VP2 protein. Bluetongue virus (BTV) VP2 is an important antigenic protein that can be used for the differential diagnosis of different BTV serotypes. Here, we generated a serotype-specific monoclonal antibody (mab) against BTVA series of peptides synthesized b...

Bonneau, B.; Ando, H.; Kawaai, K.; Hirose, M.; Takahashi-Iwanaga, H.; Mikoshiba, K., 2017: IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact. IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP<sub>3</sub>)-binding pocket of the IP<sub>3</sub> receptor (IP<sub>3</sub>R), whereas the antiapoptotic protein, Bcl2l10, binds to ano...

Zwolinski, J.; Studzinski, S., 1966: Observations on the length of the period in which foals remain with their dams. From the observation of 729 cases of weaning breed-foals from their dams. It was found that the age of the foals at weaning varied from 143 to 214 days; more than 65% of the foals were separated from the mares between the 5th and 6th month of life...