geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

"As much as possible"--an outdated concept in advanced neuroblastoma?


, : "As much as possible"--an outdated concept in advanced neuroblastoma?. Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 113: 1056-1061

Complete tumor resection is often impossible in disseminated stages of neuroblastoma. Therefore, the role of primary tumor resection in neuroblastoma patients of stage III and IV will be discussed here. Between 1972 and 1995, 66 neuroblastoma patients were operated in our department of pediatric surgery, 41 of whom were treated before 1989 and are the subject of retrospective study. Eight children belonged to stage III, 15 to stage IV and two to stage IV-S. Primary tumor resection was carried out in 19 of 25 patients with disseminated tumor stages. Total resection (RO) was achieved in three cases (16%). Microscopic tumor remains (R1) were present in four, with macroscopic remains in 12 cases. Three disseminated neuroblastomas received preoperative chemotherapeutic treatment, followed by a delayed complete operative tumor resection in two cases. Temporary tumor remission after an incomplete primary operation (R2) was achieved with adjuvant postoperative chemo- and radiotherapy in six of 12 patients. The mortality rate was high (stage III: n = 5/8, stage IV: n = 14/15, stage IV-S: n = 2/2). We recommend preoperative chemotherapy in cases of infiltrative tumor growth of stage III and generally in stage IV. This therapeutic regime improves the rate of complete tumor resection with less intraoperative complications.

US$29.90

PMID: 9101781


Other references

Babajko, S.; Tronche, F.; Groyer, A., 1993: Liver-specific expression of human insulin-like growth factor binding protein 1: functional role of transcription factor HNF1 in vivo. Tissue-specific expression of insulin-like growth factor binding protein 1 (IGFBP-1) in the liver has been studied using differentiated (H4II and C2Rev7) and dedifferentiated (H5 and C2) rat hepatoma cell lines. Northern blot analysis showed that...

Mima, E.G.O.; Andrade, R.R.; Camargo, L.A.A.; Saad, W.A., 2004: Effects of angiotensin and vasopressin V(1) receptors on water and sodium intake induced by injection of vasopressin into lateral septal area. The specific arginine(8)-vasopressin (AVP) V(1) receptors antagonist (AAVP) was injected (20, 40 and 80 nmol) into the lateral septal area (LSA) to determine the effects of selective septal V(1) receptor on water and 3% sodium intake in rats. Was...

Specks, U., 2015: Accurate relapse prediction in ANCA-associated vasculitis-the search for the Holy Grail. Journal of the American Society of Nephrology 26(3): 505-507

Pascoe, D.P., 1975: Frequency responses of hearing aids and their effects on the speech perception of hearing-impaired subjects. Eight hearing-impaired subjects were tested with a binaural master hearing aid. This aid has "on-the-head" miniature transducers and has an adjustable frequency response. Five frequency responses were used, two of them were defined by th...

Lee, Y.H.n; Kim, J.O.k; Min, D.S.k; Kim, H.S.ok; Kim, Y.S.k; Lee, C.Y.un; Ryu, S.H.; Suh, P.G.ill, 1994: Study on tyrosine phosphorylation of 95 kDa protein stimulated by granulocyte-macrophage colony-stimulating factor in differentiated human HL60 leukemic cells. Human granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine which stimulates the proliferation and differentiation of various lineage of hematopoietic cells. We examined whether GM-CSF stimulates protein phosphorylati...

Wilson, A.G.; Wood, A.W., 1969: Regional livestock production and feed freight assistance. A livestock feed-grain study is discussed, in which linear programming is used to develop the optimum pattern of 'livestock production in Canada. A model is developed based on data for 1962-63 and related to the subsidization of transportatio...

Matousková, J.; Nespůrková, L.; Rybová, R.; Janácek, K., 2008: Redox activity ofHydrodictyon reticulatum plasmalemma vesicles. Plasmalemma vesicles with preserved redox activity were prepared from nets ofHydrodictyon reticulatum. Since the walls are mechanically very resistant, a combination of partial cell-wall enzyme digestion and ultrasonic homogenization had to be use...

Veronesi B.; Jones K.; Gupta S.; Pringle J.; Mezei C., 1989: Gene probe for po message used to index acrylamide toxic neuropathy in rats. Society for Neuroscience Abstracts 15(1): 142

Dodson, C.B.; Koenig, S.R., 1997: The Farm Service Agency's limited resource interest rate program in the 1990s. The USA's Farm Service Agency (FSA) provides subsidized 'limited resource' interest rates to borrowers unable to afford regular programme rates in its direct operating and farm ownership programmes. Analysis of borrowers paying limi...

Kagawa, Nobuichl, 1961: How Japanese park trees are kept within fixed dimensions. This explains pruning methods.