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99mTc-MDP accumulation mechanisms in bone


, : 99mTc-MDP accumulation mechanisms in bone. Oral Surgery, Oral Medicine, and Oral Pathology 75(2): 239-246

The accumulation mechanisms of technetium-99m methylene diphosphonate were investigated using fetal mice calvaria, osteoblast-like cells, collagen sponges, and hydroxyapatite powder. Technetium-99m methylene diphosphonate accumulation was found consistently in the area of cells growing out from calvarial fragments cultured for 10 days. Accumulation was also seen on autoradiographs of calvarial fragments immediately fixed with 90% ethanol. The accumulated technetium-99m methylene diphosphonate in cultured calvarial fragments was removed by 100 mmol/L pyrophosphate and 378 mmol/L ethylenediaminetetraacetic acid, however, residual accumulations were still clearly visible. There was no relation between the osteoblast-like cell number and technetium-99m methylene diphosphonate accumulation. Technetium-99m methylene diphosphonate did not accumulate in collagen sponges. These findings suggest that the accumulation of technetium-99m methylene diphosphonate is by both chemical adsorption onto the surface of the hydroxyapatite in bone and incorporation into the crystalline structure of hydroxyapatite.

US$29.90

PMID: 8381217


Other references

Ryan L.J.; Linder J.C.; Martone M.E.; Groves P.M., 1990: Histological and ultrastructural evidence that dextro amphetamine causes degeneration in neostriatum and frontal cortex of rats. D-Amphetamine sulfate, continuously administered for 3 days subcutaneously via an implanted minipump, induced neural degeneration in Long-Evans and Sprague-Dawley rats at doses between 20 and 60 mg/kg/day. Using Fink-Heimer silver staining, axonal...

Hall Donald H., 1963: The maximum of sensitivity in coil-type magnetometers for rock magnetism. A common design of magnetometers for measuring rock magnetism is based on a circular double coil which acts as a detector of magnetic flux. If the linear dimensions of the coil and the distance from coil to specimen are expressed as multiples of t...

Torres, L.M.; Cabrera, J.; Martínez, J.; Calderón, E.; Fernández, S.; Chaves, J., 2005: The specific cox-2 inhibitor valdecoxib provides effective analgesia after inguinal hernia surgery. To compare 3 oral analgesic doses--valdecoxib 20 mg, valdecoxib 40 mg and controlled-release diclofenac 75 mg--to placebo in the treatment of pain after inguinal herniorrhaphy. An international multicenter double-blind placebo-controlled trial com...

Silva, D.S.; Pereira, L.M.G.; Moreira, A.R.; Ferreira-da-Silva, F.; Brito, R.M.; Faria, T.Q.; Zornetta, I.; Montecucco, C.; Oliveira, P.; Azevedo, J.E.; Pereira, P.J.B.; Macedo-Ribeiro, S.; do Vale, A.; dos Santos, N.M.S., 2013: The apoptogenic toxin AIP56 is a metalloprotease A-B toxin that cleaves NF-κb P65. AIP56 (apoptosis-inducing protein of 56 kDa) is a major virulence factor of Photobacterium damselae piscicida (Phdp), a Gram-negative pathogen that causes septicemic infections, which are among the most threatening diseases in mariculture. The tox...

Yakovlev O.I.; Kosolapov A.I., 1980: Effects of the oxygen partial pressure on evaporation from rock melts. Geochemistry International 17(1): 115-119

Peltier, M.A.G., 1959: A note on the floral biology of cultivated rice (O. sativa L.) in the conditions obtaining at Lake Alaotra (Madagascar). Information is given for 14 varieties on the time of panicle exsertion, time between the opening of the first and last flowers on the panicle, duration of the flowering period of the whole plant, order of flowering of the panicles of a single plan...

Eisemann, J.H., 1996: Impact of beta -adrenergic agonists on growth and metabolism of meat animals. The beta -adrenergic agonists (BAA) are a group of compounds that mimic the activities of adrenalin and noradrenaline. Administration to sheep, cattle, pigs and poultry results in improved weight gain, feed conversion efficiency and dressing perce...

Pizzolato, F.; Fiorio, M.; Cesari, P., 2012: Motor system modulation for movement direction and rotation angle during motor imagery. Transcranial Magnetic Stimulation (TMS) studies have shown that the motor system is facilitated when we imagine performing motor actions. However, it is not clear whether the individual s motor system modulates bilaterally and selectively for task...

Breining H., 1969: Truncus and pseudotruncus. Beitraege zur Pathologischen Anatomie und zur Allgemeinen Pathologie 140(1): 1-22

Gilby, K.L., 2009: Investigating epigenetic influences on seizure disposition. Rats selectively bred to be seizure-prone versus resistant naturally exhibit behaviors, neuroanatomy and physiology that are reminiscent of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) in humans. Evidence sug...