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A double-blind, placebo-controlled, crossover, study to evaluate the efficacy of subcutaneous sumatriptan in the treatment of atypical facial pain


, : A double-blind, placebo-controlled, crossover, study to evaluate the efficacy of subcutaneous sumatriptan in the treatment of atypical facial pain. International Journal of Neuroscience 86(3-4): 301-309

A double-blind, placebo-controlled crossover study was undertaken to assess the efficacy and tolerability of sumatriptan in patients with atypical facial pain. Patients were aged 18-65 years and had at least a 6 months history of atypical facial pain. A total of 19 patients were recruited and assessed for pain scores (total, sensory and affective) by using a short form McGill pain questionnaire preinjection and and at 60 and 120 minutes after subcutaneous injection of sumatriptan (6 mg) or placebo. Safety and tolerability was assessed by recording adverse events during and after the injection. One patient received only one treatment since her pain symptoms resolved after the first treatment. Rest of the patients returned to the clinic 3-6 weeks later and received alternate treatment for atypical facial pain in the same fashion as on the first occasion. Treatment of patients with sumatriptan produced significant relief in sensory, affective and total pain at 120 minutes postinjection (P < .05). Sumatriptan failed to produce a significant reduction in sensory and total pain scores at 60 minutes following treatment, however the result was statistically significant for the affective pain score (P < .05). No death or other serious adverse events were reported. No patient was withdrawn from the study due to an adverse event. However, all the patients treated with sumatriptan experienced one or more adverse events. The most common reported adverse symptoms during the sumatriptan treatment period were injection site reactions, headache, feeling of heaviness, warm or hot sensation and disorders of mouth or tongue. However, most of these side effects were mild and transient. In conclusion, this study points towards some beneficial effect of a single subcutaneous injection of sumatriptan in the treatment of atypical facial pain. However, this data is not sufficient to suggest the clinical utility of subcutaneous sumatriptan (6 mg) for the management of atypical facial pain. Further studies are necessary to test the effects of prolonged subcutaneous and oral multiple dose administration of sumatriptan for the treatment of atypical facial pain.

US$29.90

PMID: 8884400


Other references

Hui-Ping Zhang; William H.C.addock; Richard O.L.ase; Wei-tao Wang; Dao-Yang Yuan; Pei-Zhen Zhang; Peter Molnar; De-Wen Zheng; Wen-Jun Zheng, 2012: Magnetostratigraphy of the Neogene Chaka basin and its implications for mountain building processes in the north-eastern Tibetan Plateau. Magnetostratigraphy of sedimentary rock deposited in the Chaka basin (north-eastern Tibetan Plateau) indicates a late Miocene onset of basin formation and subsequent development of the adjacent Qinghai Nan Shan. Sedimentation in the basin initiate...

Khokhlov, D.K., 1955: Tuberculous osteitis around the knee and its pathomorphological characteristics. Ortopediia Travmatologiia i Protezirovanie 1: 25-32

Shneerson, J.M., 1995: What next after ICU for the COPD patient?. Monaldi Archives for Chest Disease 50(2): 79-80

Lin, Y-Huei.; Simmonds, H.Anne.; Stollar, V., 2002: Restriction of a Sindbis virus mutant in BHK cells and relief of the restriction by the addition of adenosine. SV(PZF) is a mutant of Sindbis virus (SV) which we selected on the basis of its ability to replicate in mosquito cells treated with pyrazofurin (PZF), a drug which inhibits pyrimidine nucleotide biosynthesis (Lin et al., 2000, Virology 272, 61-71)...

Madhavi, R.; Triveni Lakshmi, T., 2013: Community ecology of the metazoan parasites of the Indian mackerel Rastrelliger kanagurta (Scombridae) from the coast of Visakhapatnam, Bay of Bengal. One hundred and eighty four specimens of the mackerel <i>Rastrelliger</i><i>kanagurta</i> collected from fish landings at Visakhapatnam coast, Bay of Bengal, between January 26 and 27, were examined for analysis of their me...

Poll V., 1978: The prediction of birth weight in the breech fetus. British Journal of Radiology 51(608): 647

Goldberg, R.J.; Simundson, S., 1991: Managing Medicare reimbursement on medical-psychiatry units. Many general hospitals are confronting issues of financial strain precipitated to a large extent by Medicare payment reductions. The viability of psychiatry programs within general hospitals more than ever depends upon some demonstration of their...

Sherma, J.; Fried, B., 2015: Thin-Layer and High-Performance Thin-Layer Chromatographic Analysis of Biological Samples. Advances in Chromatography 49: 401-421

Kemp, D.E.; Muzina, D.J.; McIntyre, R.S.; Calabrese, J.R., 2008: Bipolar depression: trial-based insights to guide patient care. For the majority of patients with bipolar disorder, major depressive episodes represent the most debilitating and difficult-to-treat illness dimension. Patients spend significantly more time depressed than manic or hypomanic, and attempt suicide m...

Owsley W.F.; Orr D.E.Jr; Tribble L.F., 1981: The effects of sodium bi carbonate on performance of pigs weaned at 4 weeks of age. Journal of Animal Science 53(SUPPL 1): 52