+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A study on activity of beta-glucuronidase in serum and secretion from upper respiratory tract in patients with head and neck malignant tumors

, : A study on activity of beta-glucuronidase in serum and secretion from upper respiratory tract in patients with head and neck malignant tumors. Zhonghua Er Bi Yan Hou Ke Za Zhi 31(3): 181-184

Beta-glucuronidase (beta-GD) activity in serum and upper respiratory tract (URT) secretion in patients with head and neck malignant tumors (HNMT) was studied. Subjects included 40 HNMT patients, 40 healthy volunteers and 40 patients with benign tumors of the head and neck region. The results showed that there was no statistically significant difference of serum beta-GD level among the three groups. The same was true for URT secretion between the normal control and benign tumor groups. beta-GD level in URT secretion was higher in HNMT group than in other groups (P < 0.001). Using healthy subjects' average beta-GD level plus two standard difference as positive standard, the sensitivity, reliability and specificity of the test were 85.0%, 92.5% and 100% respectively. beta-GD levels were higher in patients with advanced tumors and metastases. One year follow-ups of six patients showed that beta-GD level change in URT secretion was in accordance with clinical manifestations. These results suggest that assay of beta-GD level in URT secretion can be used as a valuable supplimental parameter in early diagnosis of HNMTs, their clinical staging, evaluation of therapeutic effectiveness and detection of recurrence and metastases. In addition, this method has the advantage of easy, prompt, result specificity, sensitivity and reliability.


PMID: 9639722

Other references

Wunderlich, G.R.; Raymond, R.; Nobrega, J.N.; Vaccarino, F.J., 1999: Region-specific decreases in CCKB receptor binding in animals demonstrating greater anxiety-like responding in rodent models of anxiety. Society for Neuroscience Abstracts 25(1-2): 66

Blaskett K.S.; Woodcock J.T., 1963: Ore dressing developments in Australia 1962. Part 2. Gold ore treatment, uranium ore treatment, beach sands, iron ore treatment, tin-tungsten ore treatment, miscellaneous, research. Mining and Chemical Engineering Review 55(8): 30-43

Ratzmann, K.P.; Witt, S.; Schulz, B.; Jahr, D.; Heinke, P., 1981: Effect of a sugar-free reducing diet in persons with obesity and hyperinsulinism : observations for two to six years. After assessment of carbohydrate tolerance and insulin secretion in response to 2-h glucose infusion, 63 obese persons, 41.0 plus or minus 3.8 years old, with hyperinsulinism, were prescribed and conscientiously adhered to a sugar-free diabetic di...

Gamble, P., 1948: Primary carcinoma. Mississippi Doctor 26(2): 28-28

Stone, W., 1900: Descriptions of a new Rabbit from the Liu Kiu Islands and a new Flying Squirrel from Borneo. Proceedings of the Academy Philadelphia, 460-463

Sung, K-Yong.; Kim, Y-Hwan.; Lee, S-Koo.; Lee, S-Yeul., 2014: An unusual presentation of pleomorphic adenoma: nasal ala. Pleomorphic adenomas arising from nonsalivary glands are not common, whereas they are the most common of all salivary gland tumors. They have been reported to arise from the nasal septum, maxillary sinus, lacrimal gland, etc. However, no cases of...

D.C.sare, M.; Zunino, F.; Pace, S.; Pisano, C.; Pratesi, G., 2000: Efficacy and toxicity profile of oral topotecan in a panel of human tumour xenografts. On the basis of their mechanism of action (cell killing during DNA replication) and the potential reversibility of the drug effects, protracted therapy with camptothecins is reported to provide optimal antitumour effects. Furthermore, oral adminis...

Meyer, E., 1985: Distribution, activity, life-history and standing crop of Julidae (Diplopoda, Myriapoda) in the central High Alps (Tyrol, Austria). The research area includes subalpine meadows, alder communities, dwarf-shrub heaths, lichen heaths and highalpine meadows (1960 m-3090 m a.s.l.). The material consists of 4419 Julidae (31.6% adult) collected by extraction of litter samples (66.4%)...

Rydelek Paul, 2007: New Madrid strain and postseismic transients. Eos, Transactions, American Geophysical Union 88(5): 60-61

E.M.ghraby A.M.; Ezzat A.; Saleh H.H., 1972: Fat metabolism in tilapia zillii part 1 seasonal variation in the general condition and feeding activity of tilapia zillii from lake mariut egypt. Bulletin of the Institute of Oceanography & Fisheries 2: 297-313