geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Acute and chronic animal models for excessive dermal scarring: quantitative studies


, : Acute and chronic animal models for excessive dermal scarring: quantitative studies. Plastic and Reconstructive Surgery 100(3): 674-681

Excessive scarring in the form of keloids and hypertrophic scars continues to be a clinical problem for some patients. The lack of an animal model for such scarring has been an obstacle to studying the cellular and molecular biology of these entities. Previous observations made by the authors that some surgical scars in the rabbit ear remain raised for months after wounding prompted us to investigate whether the rabbit ear might provide a model by which to study excessive dermal scarring. After establishing the model in preliminary study, 40 excisional wounds, 6 mm in diameter, were created over the ventral surface of rabbit ears. Elevated scars were treated with either intralesional triamcinolone acetonide or saline at day 16 postwounding. On day 22, 25 scar wounds were used for thorough histomorphometric analysis, 15 wounds were eliminated prior to analysis because of invagination of epithelial tissue, which made analysis difficult. Total area of scar and Hypertrophic Index, a ratio comparing scar prominence with the thickness of adjacent unwounded tissue, were measured for 25 (62 percent) of the resulting scars. Both total area of scar and Hypertrophic Index were found to be significantly decreased in the steroid-treated group (p < 0.02 and < 0.03, respectively). In a chronic form of this model, in which larger excisions were taken, an excessive accumulation of both new collagen and cartilage over 9 months was observed. An animal model for excessive dermal scarring that allows quantitation of scar formation and, at an early stage, can be modulated in a predictable way with intralesional corticosteroid treatment is presented. This model may parallel hypertrophic scarring in humans and thus might provide a tool by which to study its pathophysiology and objectively evaluate therapeutic modalities.

US$29.90

PMID: 9283567


Other references

Samson, E.I.; Kimlach, L.F., 1965: Effect of therapy to prevent recurrences of peptic ulcers on the courie of the disease. The paper reports on 1029 cases of patients with gastroduodenal ulcer treated by antirelapse therapy during the period of remission. This provided for rational working conditions and regime, regular, full-value food rich in vitamins, diet twice a...

Cedeno, L.; Carrero, C.; Quintero, K., 2000: La quema gomosa del tallo causada por Didymella bryoniae en transplantes de patilla en Merida, Venezuela. D. bryoniae, teleomorph of Phoma cucurbitacearum, is reported as causal agent of gummy stem blight disease which occurred (april 1999) on watermelon seedlings (Citrullus lanatus), at El Llano locality of San Juan de Lagunillas, Merida State, Venez...

Vahidnezhad, H.; Youssefian, L.; Saeidian, A.Hossein.; Mahmoudi, H.Reza.; Touati, A.; Abiri, M.; Kajbafzadeh, A-Mohammad.; Aristodemou, S.; Liu, L.; McGrath, J.A.; Ertel, A.; Londin, E.; Kariminejad, A.; Zeinali, S.; Fortina, P.; Uitto, J., 2017: Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy. Epidermolysis bullosa (EB) is caused by mutations in as many as 19 distinct genes. We have developed a next-generation sequencing (NGS) panel targeting genes known to be mutated in skin fragility disorders, including tetraspanen CD151 expressed in...

Hoy, J.F.; Hansson, B.G.; Dimitrakakis, M.; Gust, I.; Lucas, C.R., 1984: Delta agent infection in Melbourne. Evidence of infection with delta agent was sought in 284 patients with acute hepatitis B referred to Fairfield Hospital, Melbourne, between July 1, 1981, and June 30, 1982 and in 127 hepatitis B surface antigen (HBsAg) carriers. Acute and convales...

Byers P.H., 1991: Mutations in the col1a1 gene of type i collagen. American Journal of Human Genetics 49(4 SUPPL): 70

Lamming, D.W.; Sabatini, D.M., 2014: A Central role for mTOR in lipid homeostasis. The mechanistic target of rapamycin (mTOR) signaling pathway regulates many fundamental metabolic and physiological processes, including lipid metabolism. We explore recent findings on the role of mTOR in lipid homeostasis, with an emphasis on rec...

Bethlahmy, N., 1962: First year effects of timber removal on soil moisture. Soil moisture was sampled at 4 different levels, once a month from late spring until the late autumn rains, in (1) clear-felled areas, and (2) adjacent untouched forest, in the region of Portland, Oregon. The average observed maximum depletion (me...

Wang, P.; Chen, J.; Zheng, A.; Nie, Y.; Shi, X.; Wang, W.; Wang, G.; Luo, M.; Liu, H.; Tan, L.; Song, X.; Wang, Z.; Yin, X.; Qu, X.; Wang, X.; Qing, T.; Ding, M.; Deng, H., 2004: Expression cloning of functional receptor used by SARS coronavirus. We have expressed a series of truncated spike (S) glycoproteins of SARS-CoV and found that the N-terminus 14-502 residuals were sufficient to bind to SARS-CoV susceptible Vero E6 cells. With this soluble S protein fragment as an affinity ligand, w...

Hansawasdi, C.; Kawabata, J., 2006: Alpha-glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2. The effects of brewing time on dry weight content and alpha-glucosidase inhibitory active component released from mulberry (Morus alba) tea were studied. Different tea products showed significant differences in inhibitory activity against both suc...

Mulloy, K.B.; Sumner, S.A.; Rose, C.; Conway, G.A.; Reynolds, S.J.; Davidson, M.E.; Heidel, D.S.; Layde, P.M., 2014: Renewable energy and occupational health and safety research directions: a white paper from the Energy Summit, Denver Colorado, April 11-13, 2011. Renewable energy production may offer advantages to human health by way of less pollution and fewer climate-change associated ill-health effects. Limited data suggests that renewable energy will also offer benefits to workers in the form of reduce...