geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Acute coronary syndromes: an update. I. Pathogenesis and drug therapy


, : Acute coronary syndromes: an update. I. Pathogenesis and drug therapy. Herz 26(2): 99-110

Unstable angina accounts for more than one million hospital admissions annually. 6-8% of patients with this condition have non-fatal myocardial infarction or die within the first year after diagnosis. Recently, the term "acute coronary syndromes" has been used to describe the spectrum of conditions that includes unstable angina, non-Q-wave myocardial infarction (which generally presents without ST-segment elevation), and Q-wave myocardial infarction (which generally presents with ST-segment elevation). Disruption of a formed plaque is a complex pathologic process that is central to the initiation of the acute coronary syndromes. Local thrombosis occurring after plaque disruption results from complex interactions among the lipid core, smooth-muscle cells, macrophages, and collagen. Multiple huge clinical trials confirmed that aspirin reduces the risk of death from cardiac causes and fatal and non-fatal myocardial infarction by about 50-70% in patients presenting with unstable angina. Ticlopidine may be substituted for aspirin in patients with hypersensitivity to aspirin or gastrointestinal intolerance. Clopidogrel acts similarly to ticlopidin but has fewer side effects than ticlopidine and has not been reported to cause neutropenia. High-risk patients with refractory unstable angina and elevated troponin levels may have substantial benefit of glycoptotein (GP) IIb/IIIa inhibition. Current practice guidelines support the use of the combination of unfractionated heparin and aspirin for the treatment of unstable angina. Clinical studies have demonstrated that the incidence of the composite end point of death, myocardial infarction, or recurrent angina was lower with enoxaparin than with unfractionated heparin. Beta-blockers, nitrates, and calcium-channel blockers are useful for antiischemic therapy in patients with acute coronary syndromes.

US$29.90

PMID: 11349620


Other references

Anonymous, 1979: Obituaries: Carl E. Killion, Sr. American bee journal 119(8): 562

He, J.; Ma, J.; Lai, D-Wan.; Zhang, Y-min.; Sun, W-Ji., 2012: A new triterpenoid saponin from the roots of Phytolacca acinosa. A new triterpenoid saponin, named esculentoside T (1), together with five known compounds (2-5), was isolated from the roots of Phytolacca acinosa. The structures of these compounds were elucidated on the basis of spectral data.

Kent P.E., 1967: The sub-Carboniferous basement in northern England; a symposium. Papers on structural and age relationships and other features of the pre-Carboniferous basement rocks of northern England have been compiled, together with discussion (including written contributions); the papers, presented at a meeting held at Le...

Thomes, J.C.; Ratinaud, M.H.; Julien, R., 1983: Dimeric glutamyl transfer rna synthetases ec 6.1.1.17 from wheat kinetic properties and functional structures. The Km in the tRNA aminoacylation reaction were studied for the 3 dimeric glutamyl-tRNA synthetases C, P and E. The values were the following: for tRNA, 0.20 .mu.M, 0.20 .mu.M and 0.44 .mu.M for glutamic acid, 10 .mu.M, 83 .mu.M and 83 .mu.M; for...

Filipović, L.; Romić, M.; Romić, D.; Filipović, V.; Ondrašek, G., 2017: Organic matter and salinity modify cadmium soil (phyto)availability. Although Cd availability depends on its total concentration in soil, it is ultimately defined by the processes which control its mobility, transformations and soil solution speciation. Cd mobility between different soil fractions can be significan...

Ahmed, S.; Evans, H.J., 1960: The response of soybean plants to cobalt in the absence of supplied nitrogen. Abstract of a paper presented to the American Society of Plant Physiologists, August, 1960. In the absence of added Co plants were less vigourous and showed symptoms of mild N deficiency. Addition of 1 ppb Co increased the N content and (by 30-81...

Perumal, R.P.ulraj, T.; Krishnamoorthy, K.; Kandasamy, P., 1979: Effect of environment, container on storage quality of pesticides. Food farming and agriculture 12(3): 53-55

Sheagren, J.N., 1984: Staphylococcus aureus. The persistent pathogen (second of two parts). New England Journal of Medicine 310(22): 1437-1442

Reiter, S.; Campillo Rodriguez, C.; Sun, K.; Stopfer, M., 2015: Spatiotemporal Coding of Individual Chemicals by the Gustatory System. Four of the five major sensory systems (vision, olfaction, somatosensation, and audition) are thought to use different but partially overlapping sets of neurons to form unique representations of vast numbers of stimuli. The only exception is gusta...

Stokland, E.; Hellstrom, M.; Jakobsson, B.; Sixt, R., 1999: Imaging of renal scarring. Children with urinary tract infection should be investigated and followed up, as those with pyelonephritis may develop renal scarring. In this review, after discussing the advantages and disadvantages of various imaging modalities for diagnosis of...