+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Aldehyde reductase gene expression by lipid peroxidation end products, MDA and HNE

, : Aldehyde reductase gene expression by lipid peroxidation end products, MDA and HNE. Free Radical Research 33(6): 739-746

Membrane lipid peroxidation results in the production of a variety of aldehydic compounds that play a significant role in aging, drug toxicity and the pathogenesis of a number of human diseases, such as atherosclerosis and cancer. Increased lipid peroxidation and reduced antioxidant status may also contribute to the development of diabetic complications. This study reports that lipid peroxidation end products such as malondialdehyde (MDA) and 4-hydroxynonenal (HNE) induce aldehyde reductase (ALR) gene expression. MDA and HNE induce an increase in intracellular peroxide levels; N-Acetyl-L-cysteine (NAC) suppressed MDA- and HNE-induced ALR gene expression. These results indicate that increased levels of intracellular peroxides by MDA and HNE might be involved in the upregulation of ALR.


PMID: 11237096

Other references

Ahmad M.; Sattar A.; Hussain A.; Jamil M.; Farooqi W.A.; Hussain A.M., 1972: Some physicochemical changes in irradiated ber zizyphus jujuba during storage and ripening. Pakistan Journal of Scientific & Industrial Research 15(3): 163-166

Su, X.W.; Lee, S.Y.; Mitchell, R.M.; Stephens, H.E.; Simmons, Z.; Connor, J.R., 2013: H63D HFE polymorphisms are associated with increased disease duration and decreased muscle superoxide dismutase-1 expression in amyotrophic lateral sclerosis patients. H63D HFE polymorphisms increase the risk of neurodegenerative disorders and, specifically, may increase amyotrophic lateral sclerosis (ALS) risk. Investigating the physiological alterations induced by H63D polymorphisms in ALS patients may elucida...

McNally, N.J.; George, K.C.; de Ronde, J., 1979: Recovery from sublethal damage by acutely hypoxic tumour cells in vivo and in vitro. The ability of acutely hypoxic tumour cells to recover from sublethal damage following irradiation in vivo and in vitro has been measured using a single tumour system. The methods of assay were tumour growth delay, local tumour control and tumour...

Bockus, B.J.; Schaffhausen, B., 1987: Phosphorylation of polyomavirus large T antigen: effects of viral mutations and cell growth state. Phosphorylation is responsible for the shift in electrophoretic mobility of polyomavirus large T antigen observed in pulse-chase or continuous-labeling experiments. Phosphorylated forms migrated more slowly than newly synthesized [35S]methionine l...

Anonymous, 1982: Advirtisement/Classified. Environmental Science & Technology 16(10): 586a-586a

Wawer, A.A.; Sharp, P.A.; Perez-Moral, N.; Fairweather-Tait, S.J., 2013: Evidence for an enhancing effect of alginate on iron availability in Caco-2 cells. The potential use of alginates as a vehicle for water-soluble (bioavailable) iron for fortifying food products was examined using a Caco-2 cell model system. Cell monolayers were exposed to alginates with various mannuronic to guluronic acid ratio...

Marko, M.; Kressin, M.; Schnorr, B., 1992: Differentiation of the bovine ruminal epithelium during the intrauterine development. The prenatal development of the bovine ruminal epithelium was studied with light- and electromicroscopical techniques. During the period of the nonstratified epithelium a pseudostratified epithelium is found in the dorso-cranial part, whereas the...

Blantz, R.C.; Konnen, K.S., 1977: Relation of distal tubular delivery and reabsorptive rate to nephron filtration. The tubuloglomerular feedback hypothesis states that filtration rate in a single nephron unit (SNGFR) is controlled or modified through variations in the rate of either distal delivery or tubular reabsorption in that same nephron. We have reexamin...

Smithsonian Institution., 1967: Annual report for the year ending June 30,1967. Smithsonian Year, 1-515

Grosse Wilde H., 1984: Hla dr dq lb and ta 10 specificities of 9th workshop homozygous typing cells. Albert, E. P. Baur And W. R. Mayr (ed.). Histocompatability Testing: New York, N.y., Usa; Berlin, West Germany. Illus. 243-248