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Anti-Toxoplasma effect of activated mouse macrophages induced by interferon-gamma combined with TNF-alpha

, : Anti-Toxoplasma effect of activated mouse macrophages induced by interferon-gamma combined with TNF-alpha. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 17(6): 350-352

To compare the inhibitory effect of the macrophages activated by IFN-gamma combined with TNF-alpha against RH strain and Fukaya strain. The average parasite proliferation rates of the two strains within the cytokine-activated M phi s were calculated at different times post-challenge, the nitric oxide (NO) levels in the medium supernatant were simultaneously determined. In the macrophages activated by 100 U each of IFN-gamma and TNF-alpha, the invaded tachyzoites of RH strain were completely killed, while the invaded tachyzoites of Fukaya strain remained slow proliferation with significantly lower levels of NO detected at 24 h post challenge. The difference in the anti-Toxoplasma effect of the activated macrophages against RH and Fukaya strains might be attributed to the different amount of NO produced by the macrophages.


PMID: 12563732

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