geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Antiviral activity of 2'-deoxy-2'-fluoroguanosine against influenza and herpes simplex viruses in cultured cells


, : Antiviral activity of 2'-deoxy-2'-fluoroguanosine against influenza and herpes simplex viruses in cultured cells. Voprosy Virusologii 46(5): 40-42

High antiviral activity of 2'-deoxy-2'fluoroguanosine (2'-D-2'-FG) was observed in chicken embryo cells infected with FPV/Rostock/34 (H7N1) influenza virus and herpes simplex virus (HSV) type I (strain 1C). 50% inhibitory concentration (IC50) of 2'-D-2'-FG was 1.44 microM for FPV and 0.093 microM for HSV. IC50 of remantadine hydrochloride, ribavirin (FPV), and acycloguanosine (HSV) were < 0.46, 14.4, and 0.08 microM, respectively. Anti-HSV activity was confirmed in Vero cells: IC50 < 0.34 microM for 2'-D-2'-FG and IC50 < 0.044 microM for acycloguanosine.

US$29.90

PMID: 11715709


Other references

Lehmkuhl, H.D.; Gough, P.M., 1977: Investigation of causative agents of bovine respiratory tract disease in a beef cow-calf herd with an early weaning program. Serum samples were collected from early weaned fall calves shortly after the onset of respiratory tract disease. Antibody titers to infectious bovine rhinotracheitis (IBR) virus, parainfluenza type 3 (PI-3) virus, bovine viral diarrhea (BVD) virus...

Chernov, N.N.; Peterson, O.A., 1977: Study of economically useful forms of Abies sibirica in the central Urals. The results are presented of a study of variation in A. sibirica and useful forms are singled out.

Klein, S.P.; Bohannan, H.M.; Bell, R.M.; Disney, J.A.; Foch, C.B.; Graves, R.C., 1985: The cost and effectiveness of school-based preventive dental care. The National Preventive Dentistry Demonstration Program assessed the cost and effectiveness of various types and combinations of school-based preventive dental care procedures. The program involved 20,052 first, second, and fifth graders from five...

Duffy, T.A.; Picha, M.E.; Won, E.T.; Borski, R.J.; McElroy, A.E.; Conover, D.O., 2010: Ontogenesis of gonadal aromatase gene expression in atlantic silverside (Menidia menidia) populations with genetic and temperature-dependent sex determination. Cytochrome P450 aromatase (P450arom), an enzyme that converts testosterone to 17beta-estradiol, is an important mediator of sex determination in teleosts with genetic sex determination (GSD) and temperature-dependent sex determination (TSD). We co...

Liang, J.; Kulasiri, D.; Samarasinghe, S., 2016: Ca2+ dysregulation in the endoplasmic reticulum related to Alzheimer's disease: A review on experimental progress and computational modeling. Alzheimer's disease (AD) is a devastating, incurable neurodegenerative disease affecting millions of people worldwide. Dysregulation of intracellular Ca(2+) signaling has been observed as an early event prior to the presence of clinical sympt...

Hembree, J.H.; Andrews, J.T., 1976: Microleakage of several acid-etch composite resin systems: a laboratory study. Operative Dentistry 1(3): 91-97

Ishikawa, S.; Takeda, A.; Akimoto, M.; Kounoike, N.; Uchinuma, E.; Uezono, Y., 2014: Effects of neuropeptides and their local administration to cutaneous wounds in sensory-impaired areas. Wound healing in sensory-impaired areas such as diabetic foot and spinal cord injuries is intractable. Previous studies have shown that delayed wound healing both of wound contraction and epithelialization in denervated rat skin. The aim of this s...

Cueto G.S.A., 1990: Production of goats in the Mexicali Valley. In 1989 there were 26 528 goats in the Mexicali Valley in north-eastern Mexico, where the temp. reaches 40 degrees - 45 degrees C in June-Sep. and falls to -7 degrees in winter. Of the goats, 53.19% were kept by owners with no land, and 75.9, 19.8...

Rui Jusheng; D.M.quin; Wang Changxie; Chen Haiming, 1982: Histo-pathological observations of the rat oesophagus and forestomach after long-term feeding of Geotrichum candidum Link. The proportion of animals with basal cell hyperplasia in either the oesophagus (91.3%) or forestomach (98%) was significantly increased in rats fed varying amounts of G. candidum compared to controls (80 and 85%, respectively). No malignant lesion...

Weiner, H.L.; Komagata, Y., 1998: Oral tolerance and the treatment of rheumatoid arthritis. Springer Seminars in Immunopathology 20(1-2): 289-308