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Appearance of target-specific guidance information for regenerating axons after CNS lesions

, : Appearance of target-specific guidance information for regenerating axons after CNS lesions. Neuron 11(5): 975-983

During development of the vertebrate visual system, an orderly projection of ganglion cells from the retina onto the superior colliculus (SC) is established. Mechanisms that might govern this process include the coordinated action of guidance and corresponding receptor molecules that are specifically distributed on the axons and their targets. In birds and mammals, information for axonal guidance and targeting appears to be confined to the time when the retinocollicular projection is being formed. Here we show that putative guidance activities for temporal and nasal retinal axons, which are not detectable in the normal adult SC, appear after optic nerve transection in adult rats. Both embryonic and adult retinal axons are able to respond to these guiding cues, although the guidance activities detectable in the deafferented adult rat SC might be different from those found during development. These findings imply that it might be possible to reestablish an ordered projection after lesions in the adult mammalian visual system.


PMID: 8240818

Other references

Baylet, R.; Sinegre, F.; Chapat, M.; Riviere, Y., 1975: Salmonella isolated in effluents of Herault stations. Investigation for Salmonella in the effluents of 97 purification plants has underlined the importance of Salmonella endemy in the county of Herault before and during the summer. The existing systems of purification do not eliminate sufficient path...

Kumerloeve, H., 1975: Schwalben als Lachmowenopfer. Ornithologische Beobachter, 713: 122

Fominykh V.G., 1974: Fluorine and chlorine in the coexisting apatites and amphiboles in the rocks and ores of the titanomagnetite deposits of the Urals. Geochemistry International 11(2): 354-356

Medintz, I.L.; Berti, L.; Mathies, R.A., 2002: Novel energy transfer fluorescence labeling cassette. Biotechniques 32(2): 270, 272-270, 272

Mencière, M-Louis.; Ferraz, L.; Mertl, P.; Vernois, Jël.; Gabrion, A., 2016: Arthroscopic tibiotalocalcaneal arthrodesis in neurological pathologies: outcomes after at least one year of follow up. The main complications of open tibiotalocalcaneal arthrodesis are wound healing disorders and nonunion. Our hypothesis was that arthroscopy and interlocking intramedullary nailing decrease these complications. We retrospectively reviewed six patie...

Voigt, J.; Havemann, D.; Seemann, K., 1979: Gas gangrene following open injuries. Hefte Zur Unfallheilkunde 138: 344-347

O'brien R.M.; Houslay M.D.; Milligan G.; Hall A.; Siddle K., 1986: The insulin receptor tyrosyl kinase fails to phosphorylate the guanine nucleotide regulatory proteins n i n o and p21. Biochemical Society Transactions 14(6): 1015

Verkade, H.; Heath, J.K., 2009: Wnt signaling mediates diverse developmental processes in zebrafish. A combination of forward and reverse genetic approaches in zebrafish has revealed novel roles for canonical Wnt and Wnt/PCP signaling during vertebrate development. Forward genetics in zebrafish provides an exceptionally powerful tool to assign ro...

Soller, B.J.; Hall, D.G., 2001: Energy transfer at optical frequencies to silicon-based waveguiding structures. For decades, crystalline silicon (Si) has been the semiconductor of choice for the majority of applications in microelectronics. Recent advances in material science have focused attention on the silicon-on-insulator (SOI) platform, a submicrometer...

Shapiro, I.M.; Stevenson, M.; Sinangil, F.; Volsky, D.J., 1986: Transfection of lymphoblastoid cells using DNA-loaded reconstituted Sendai virus envelopes: expression of transfected DNA and selection of transfected cells. The American Burkitt's lymphoma cell line Loukes was cotransfected with cloned BamHI K fragment of EBV DNA and a vector pSV2neo. Reconstituted Sendai virus envelopes (RSVE) loaded with DNA were used for efficient gene transfer. Two cell lines...