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Association of HELLP syndrome with autoimmune antibodies and glucose intolerance


, : Association of HELLP syndrome with autoimmune antibodies and glucose intolerance. Diabetes Care 23(6): 786-790

HELLP syndrome is a severe form of preeclampsia, characterized by hemolysis (H), elevated liver enzymes (EL), and low platelets (LP), whose pathogenesis is unclear. Autoimmunity is thought to play an important role. After the observation of development of type 1 diabetes in a patient with HELLP syndrome, we assumed a possible disease association based on autoimmune reactions. We examined 70 women with HELLP syndrome for the presence of autoimmune markers and glucose intolerance. Free thyroxine, triiodothyronine, thyroid-stimulating hormone, anti-thyroglobulin antibodies, thyroperoxidase antibodies, thyrotropin receptor antibodies, antinuclear antibodies (ANAs) and anti-DNA, islet cell antibodies, GADA, an oral glucose tolerance test, and HbA1c were determined postpartum. Patients with positive autoimmune markers or glucose intolerance were prospectively followed and repeated testing was performed. There were 60 women with a normal course of pregnancy matched for age, BMI, and number of pregnancies, which served as a control group. From the HELLP patients, 22 (31%) compared with only 6 (10%) control subjects had autoimmune antibodies (P < 0.01). There were 16 HELLP patients (23%) who exhibited only 1 kind of autoantibody (5 ANA, 9 thyroid antibodies, and 2 GADA), whereas in 6 HELLP patients (8.5%) 2 different antibodies were found. In all but 4 patients of the study group, these antibodies disappeared during 3 +/- 1.5 years of follow-up. Glucose intolerance was detected in 22 (31%) of the HELLP patients, 17 of them had impaired glucose tolerance (IGT), and 5 had diabetes, whereas only 4 subjects (6.5%) with IGT at postpartum were found in the control group (P < 0.01). During the follow-up, 2 HELLP patients were still diabetic and another 2 HELLP patients (1 GADA positive) had IGT versus 1 control subject. Our data give evidence that HELLP syndrome is associated with various autoimmune antibodies and glucose intolerance. Because glucose intolerance and/or autoimmune markers persisted during long-term follow-up in 6 patients with HELLP syndrome versus 1 in the control group, it may become advisable to reexamine patients with HELLP syndrome for detection of diabetes and autoimmune disorders.

US$29.90

PMID: 10840997


Other references

Merrill, J.E., 1991: Effects of interleukin-1 and tumor necrosis factor-alpha on astrocytes, microglia, oligodendrocytes, and glial precursors in vitro. Microglia and astrocytes undergo proliferative and differentiative changes in vivo after trauma or diseases such as multiple sclerosis (MS). Oligodendrocytes are destroyed in lesions in MS. Interleukin-1 (IL1) and tumor necrosis factor-alpha (TNF...

Ekenman, I.; Eriksson, S.A.V.; Lindgren, J.U., 1995: Bone density in medieval skeletons. We studied the most complete skeletons found in an excavation from the 14th and 15th century in central Stockholm. One hundred eighty-seven were from men and 156 from women: 241 individuals were estimated to be between 20 and 39 and 102 between 40...

Jacobi Robert D., 2002: Basement faults and seismicity in the Appalachian Basin of New York State. Landsat lineaments identified by Earth Satellite Corporation (EARTHSAT, 1997) can be groundtruthed across the Appalachian Basin of New York State (NYS). Both fracture intensification domains (FIDs) and faults are observed in outcrop along the line...

Lapiere, C.M., 1964: Contribution To The Study Of Connective Tissue Cicatrization. Memoires de L'academie Royale de Medecine de Belgique 11: 39-153

Jones, A.M.; Govan, J.R.W.; Doherty, C.J.; Dodd, M.E.; Isalska, B.J.; Stanbridge, T.N.; Webb, A.K., 2003: Identification of airborne dissemination of epidemic multiresistant strains of Pseudomonas aeruginosa at a CF centre during a cross infection outbreak. Background: Chronic Pseudomonas aeruginosa infection is a major cause of morbidity and mortality for individuals with cystic fibrosis (CF). P. aeruginosa cross infection outbreaks have recently been reported at CF holiday camps and specialist cent...

Janson, C., 2010: The importance of airway remodelling in the natural course of asthma. Asthma is associated with airflow limitation and increased decline in lung function. The underlying mechanism for this was probably that persisting inflammation leads to remodelling of the airways. To review the importance of different factors whi...

McCalley, A.E.; Kaja, S.; Payne, A.J.; Koulen, P., 2015: Resveratrol and calcium signaling: molecular mechanisms and clinical relevance. Resveratrol is a naturally occurring compound contributing to cellular defense mechanisms in plants. Its use as a nutritional component and/or supplement in a number of diseases, disorders, and syndromes such as chronic diseases of the central ner...

Gould, K.H., 2000: Beyond Jones v. Clinton: sexual harassment law and social work. In the wake of the Jones v. Clinton case, there has been a renewed interest in sexual harassment issues, particularly the chaotic case law in this important field of practice. The author urges the social work profession to resurrect its commitment...

McClintick, J.; Koller, D.L.; Pankratz, N.; Kirkwood, S.C.; Naughton, B.; Foroud, T., 2002: Parametric linkage analysis and disequilibrium methods to identify loci for complex disease. A two-step process was used to find loci contributing to the qualitative disease phenotype in the Genetic Analysis Workshop (GAW) 12 simulated data. The first step used parametric linkage analysis with a limited number of dominant and recessive mo...

Starren, E.S.; Roberts, N.J.; Tahir, M.; O'Byrne, L.; Haffenden, R.; Patel, I.S.; Partridge, M.R., 2012: A centralised respiratory diagnostic service for primary care: a 4-year audit. The literature shows that delayed or erroneous diagnosis of respiratory conditions may be common in primary care due to underuse of spirometry or poor spirometric technique. The Community Respiratory Assessment Unit (CRAU) was established to optim...