+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Attention deficit-hyperactivity disorder and asymmetry of the caudate nucleus

, : Attention deficit-hyperactivity disorder and asymmetry of the caudate nucleus. Journal of Child Neurology 8(4): 339-347

The neurologic basis of attention deficit-hyperactivity disorder (ADHD) is poorly understood. Based on previous studies that have implicated metabolic deficiencies in the caudate-striatal region in ADHD, we employed magnetic resonance imaging to investigate patterns of morphology of the head of the caudate nucleus in normal and ADHD children. In normal children, 72.7% evidenced a left-larger-than-right (L > R) pattern of asymmetry, whereas 63.6% of the ADHD children had the reverse (L < R) pattern of asymmetry of the head of the caudate nucleus. This reversal of normal asymmetry in ADHD children was due to a significantly smaller left caudate nucleus. The reversal in asymmetry of the head of the caudate was most notable in ADHD males. These results suggest that normal (L > R) morphologic asymmetry in the region of the caudate nucleus may be related to asymmetries observed in neurotransmitter systems implicated in ADHD. The behavioral symptoms of ADHD may reflect disinhibition from normal levels of dominant hemispheric control, possibly correlated with deviations in asymmetric caudate-striatal morphology and deficiencies in associated neurotransmitter systems.


PMID: 8228029

Other references

Whyman, A.E., 1970: Measurement of tritium in neat plasma and urine with a toluene/triton X-100/hyamine 10-X scintillant. International Journal of Applied Radiation and Isotopes 21(2): 81-86

Safronova O.N.; Ivan'ko O.G., 1985: Importance of a catamnestic study and mathematical analysis in predicting the length of remission in children with bronchial asthma. Pediatriya (Moscow) (4): 46-47

Agarwal, A.; Kumar, D.Ashok.; Jacob, S.; Baid, C.; Agarwal, A.; Srinivasan, S., 2008: Fibrin glue-assisted sutureless posterior chamber intraocular lens implantation in eyes with deficient posterior capsules. We report a new surgical technique that uses biological glue to implant a posterior chamber intraocular lens (PC IOL) in eyes with a deficient or absent posterior capsule. Two partial-thickness limbal-based scleral flaps are made 180 degrees apart...

Manuel, H.S., 1964: Effective Approach To Acne Problem In College Students. Clinical Medicine 71: 483-489

Gaggioli, C., 2009: Collective invasion of carcinoma cells: when the fibroblasts take the lead. Epithelial to mesenchymal transitions (EMT) have been suggested to be crucial during epithelial cancer cell invasion. However, in a three-dimensional "organotypic" invasion assay squamous cell carcinoma (SCC) cells that retain epithelial...

Bohan A.; Peter J.B., 1975: Poly myositis and dermato myositis 2nd of 2 parts. New England Journal of Medicine 292(8): 403-407

Handa, T.; Saito, H.; Miyajima, K., 1993: Eutectic mixed monolayers in equilibrium with phospholipid-bilayers and triolein-liquid phase. Triolein (TO) and phospholipids (egg yolk phosphatidylcholine, egg yolk phosphatidylethanolamine, and bovine brain phosphatidylserine) had low mutual solubilities and separated into the TO-liquid phase and phospholipid-bilayers. Spreading pressure...

Ahrens, H.; Heissenhuber, A., 1986: Some critical reflections on introducing a system of differential pricing in the milk sector. A suggestion has been made in the GFR to introduce into the EC milk market a system of differentiated producer prices granting higher prices to smaller farms on the basis of their individual milk production. This article discusses the merits and d...

Matsushima, H.; Sugai, T.; Mizuno, K.; Hachinohe, S., 2009: Stratigraphy and changes in the sedimentary environment since the middle Pleistocene in the interior of the Kanto Plain, Japan. The Middle Pleistocene to Holocene stratigraphy under the interior of the Kanto Plain was constructed by analyzing two drilling cores (GS-FK-1 and SA-GD-1). We performed sedimentary facies analysis, determined lithological compositions of gravels,...

Mauro, M.J., 2013: Editorial. Therapeutic Advances in Hematology 3(2): 79-80