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Autologous BMT for post-remission therapy in adult ALL: an immunological approach. For The French Group of Therapy of Adult ALL

, : Autologous BMT for post-remission therapy in adult ALL: an immunological approach. For The French Group of Therapy of Adult ALL. Leukemia & Lymphoma 13 Suppl 1: 95-98

Among patients included in the multicentric trial ALL87, 95 patients were randomly allocated to purged ABMT arm for post-remission therapy. Immunological phenotyping performed in patients at diagnosis allowed to assigned 51 patients (54%) to the B lineage and 34 patients (36%) to the T lineage. Only 64 patients (67%) actually received ABMT mainly because of early relapses. Fifty-two patients were depleted according to the protocol: 25 B-ALL were depleted with CD10+CD19 mAbs, 19 T-ALL with CD2+CD5+CD7 mAbs and 8 patients received an Asta-Z purged BMT. Among the 12 remaining patients, 4 received Asta-Z purged BMT and 8 an unpurged one. Using an intention to treat analysis, overall survival and event free survival were similar to results observed in chemotherapy group. This study emphasizes the importance of a precise phenotyping at ALL diagnosis which allows specific immunologic bone marrow purging for ABMT.


PMID: 8075589

DOI: 10.3109/10428199409052684

Other references

Anonymous, 2011: The John A. Hartford foundation. Journal of Gerontological Nursing 37(8): 5-6

Dono, K.; Gotoh, M.; Fukuzaki, T.; Ohzato, H.; Kanai, T.; Monden, M.; Mori, T., 1992: Low-temperature collagenase digestion: an improved islet isolation method from cold preserved pancreas. Transplantation Proceedings 24(4): 1511-1512

Sampaio, M-Manuel.; Santos, H.; Boos, W., 2003: Synthesis of GDP-mannose and mannosylglycerate from labeled mannose by genetically engineered Escherichia coli without loss of specific isotopic enrichment. We report the construction of an Escherichia coli mutant that harbors two compatible plasmids and that is able to synthesize labeled 2-O-alpha-D-mannosyl-D-glycerate from externally added labeled mannose without the loss of specific isotopic enric...

Baer A.J., 1976: Preliminary report on the Borgia Meta-anorthosite (La Tuque, Quebec, Canada). Canadian Journal of Earth Sciences = Journal Canadien des Sciences de la Terre 13(1): 84-91

Blank, M.Y., 1968: New species Athleta from Maastricht deposits of the Northern Donbas and the Crimea. Paleontologicheskij Sbornik Lemberg, 5(1): 53-58

Kohno, K.; Sato, S.; Uchiumi, T.; Takano, H.; Kato, S.; Kuwano, M., 1990: Tissue-specific enhancer of the human multidrug-resistance (MDR1) gene. Identification of cis-regulatory sequences is a first step in analyzing the regulation of the human multidrug-resistant 1 (MDR1) gene which encodes the 170-kilodalton membrane P-glycoprotein in normal tissues and tumor cells. We have studied sever...

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