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Automated discrimination and quantification of idiopathic pulmonary fibrosis from normal lung parenchyma using generalized fractal dimensions in high-resolution computed tomography images


, : Automated discrimination and quantification of idiopathic pulmonary fibrosis from normal lung parenchyma using generalized fractal dimensions in high-resolution computed tomography images. Academic Radiology 2(1): 10-18

We computed generalized fractal dimensions for high-resolution computed tomography (HRCT) images to investigate their value in the discrimination and quantification of idiopathic pulmonary fibrosis (IPF) from normal lung parenchyma. A probability distribution that was based on the pixel value in each image was used to compute capacity, information, and higher fractal dimensions for a series of 52 HRCT slices obtained from four patients. Qualitative classification of normal, mild, moderate, and severe IPF cases was achieved by computing the following parameter: DD = D0 - 2D1 + D2, where D0, D1, and D2 represents the capacity, information, and pair correlation dimensions, respectively. A multiple linear regression analysis using morphometric quantification for the set of 52 slices was tested for all possible combinations of the parameters D0, D1, D2, and D3. The generalizability of the model was tested by predicting the extent of IPF for each patient from a regression model computed with the remaining slices in the database. The best regression results were obtained using the independent parameters D1 and D2 to quantify the extent of diseased lung parenchyma. The technique was tested with 48 slices from 12 new patients. The results indicated that the extent of IPF could be predicted within the confidence limits given by the regression analysis. The extent of IPF can be predicted well within the 90% confidence interval given by the model. The width of the confidence interval decreases as the number of slices used in the linear regression model increases. This operator-independent quantitative technique may be useful in the follow-up of patients with IPF.

US$29.90

PMID: 9419518


Other references

Naylor, Aubrey W., 1941: Effect of nutrition and age upon rate of development of terminal staminate inflorescences of Xanthium pennsylvanicum. Plants low in P, K, and N were found to have the same critical daylength as plants receiving all these elements. Rate of development of terminal inflorescences of[long dash]N,[long dash]K, and[long dash]P plants was considerably affected at photop...

Bouche, M.B., 1991: Soil biophysicochemistry: a new methodology to reduce our ignorance of the causes of soil deterioration. Three techniques are outlined which use earthworms as indicators to test undisturbed soil: (1) the use of natural markers in specific soil chemical compositions related to earthworm casts; (2) isotope tracers placed in litter which are injected by...

Napier, J.A.; Bass, H.; Pengilley, R., 1985: Technical method. Fresh frozen cryosupernatant in place of fresh frozen plasma for broad spectrum coagulation factor replacement. Journal of Clinical Pathology 38(4): 475-477

Yoshihara, Y.; Kawahara, Y.; Yamada, Y.; Ikeda, S., 1992: Process for producing L-amino acids by fermentation. Bacterial strains for producing L-amino acids (lysine, glutamic acid, glutamine, arginine, isoleucine, valine, threonine, histidine, phenylalanine, tryptophan, serine, ornithine, citrulline, tyrosine, leucine and 5'-inosinic acid) and a proce...

Acevedo Y Pinilla, J.M., 1960: Bertholletia excelsa, an economic factor in Amazonia.. General information on the tree and its products, with brief recommendations for its propagation and cultivation in Colombia.

Hsi, K.L.ang; Kochersperger, M.L.; Werner, W.E.; Grimley, C.H.; Zieske, L.R.; Yuan, P.M.au, 1997: Development of a capillary LC blotting systems for low and sub-picomole sequencing sample preparation. A capillary liquid chromatography (cLC)/microblotting system, 173A MicroBlotter, has recently been developed (1,2). This newly designed system consists of a capillary LC for sample separation and an on-line microblotter for direct collection of th...

Weiss, Bahr, 1998: Annotation Routine monitoring of the effectiveness of child psychotherapy. Journal of Child Psychology & Psychiatry & Allied Disciplines 39(7): 943-950, Oct

Obokata, J., 1987: Synthesis and Assembly of the Polypeptides of Photosystem I and II in Isolated Etiochloroplasts of Wheat. Synthesis and assembly of photosystems (PS) I and II polypeptides in etiochloroplasts isolated from greening wheat (Triticum aestivum L. cv Norin 61) seedlings were studied. The isolated etiochloroplasts synthesized PSI polypeptides of 66 and 15 k...

Luhmann, M., 1967: Effect of different management and feeding on growth, composition and subsequent laying performance of pullets. In an experiment with 324 Leghorn pullets, those kept indoors all the time showed an elongation of limb measurements and an increase in comb size compared with those kept on pasture. Range-reared pullets averaged 22 eggs more per year than those r...

Kaye, R.; Goldstein, T.; Zeltsman, D.; Grande, D.A.; Smith, L.P., 2016: Three dimensional printing: A review on the utility within medicine and otolaryngology. Three dimensional (3D) printing is a novel technique that has evolved over the past 35 years and has the potential to revolutionize the field of medicine with its inherent advantages of customizability and the ability to create complex shapes with...