geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Autonomic imbalance and renal dysfunction cause loss of nocturnal decrease in blood pressure in diabetic nephropathy


, : Autonomic imbalance and renal dysfunction cause loss of nocturnal decrease in blood pressure in diabetic nephropathy. Nihon Jinzo Gakkai Shi 43(8): 639-645

Many diabetic patients with nephropathy show loss of the nocturnal decrease in blood pressure. However, the mechanism is not yet fully understood. Twenty-four-hour blood pressure in type II diabetic patients was evaluated by ambulatory blood pressure monitoring(with TM2425 A and D Co. Tokyo). The power spectrum of blood pressure was also analyzed as an index of autonomic cardiovascular modulation using the same device. The ratio of lower frequency(LF) to higher frequency(HF) of heart rate rhythmic oscillations was determined as an index of sympathovagal balance. Patients were divided into two subgroups (Diabetes mellitus group, serum creatinine level < 1.5 mg/dl, n = 25; Renal failure group, serum creatinine level > or = 1.5 mg/dl, n = 20) on the basis of renal function. Mean 24-hour, awake and asleep systolic blood pressure were 151.8 +/- 18.3(SD), 155.7 +/- 17.4 and 140.5 +/- 23.3 mmHg (Diabetes mellitus group) and 152.2 +/- 22.7, 152.6 +/- 22.1 and 150.0 +/- 26.5 mmHg (Renal failure group), respectively, which were higher(p < 0.01) than those(122.7 +/- 9.1, 126.0 +/- 10.2 and 112.9 +/- 10.7 mmHg) in age- and sex-matched control subjects(n = 20). The ratio between asleep and awake systolic blood pressure was 0.90 +/- 0.10 (Control group) and 0.90 +/- 0.11(Diabetes mellitus group), which were lower(p < 0.01) than that(0.98 +/- 0.09) in the Renal failure group. The Control and Diabetes mellitus groups showed a high awake mean LF/HF power ratio(1.91 +/- 0.55 and 1.95 +/- 0.48). On the other hand, the Renal failure group showed a low ratio (1.50 +/- 0.46) (p < 0.01), but each group showed no significant difference in the asleep mean LF/HF power ratio. These findings suggest that sympathovagal imbalance is worse in the waking hours in diabetic nephropathy patients with renal dysfunction, and this causes loss of the nocturnal decrease in blood pressure.

US$29.90

PMID: 11808074


Other references

Svenson, B.; Eriksson, T.; Kronström, M.; Palmqvist, S., 1994: Image quality of intraoral radiographs used by general practitioners in prosthodontic treatment planning. A number of studies have shown a low standard of radiographic image quality in general dental practices. Image quality was evaluated on 1094 radiographs from 100 consecutive cases submitted to a dental insurance office for approval of planned pros...

Atalik, K.E.; Kiliç, M.; Doğan, N., 2009: Role of the nitric oxide on diazoxide-induced relaxation of the calf cardiac vein and coronary artery during cooling. The effects of cooling (to 28 degrees C) on the vasodilation induced by diazoxide (10(-9)-3 x 10(-4) M) on carbachol-pre-contracted calf cardiac vein and coronary artery and the role of nitric oxide in these effects were analyzed. Diazoxide produc...

Goetghebuer, M., 1935: Un Culicoides nouveau du Bas-Congo. C. wansoni [female]* (p.477).

Anderson, D.E.J.; Athanasiou, K.A., 2008: Passaged goat costal chondrocytes provide a feasible cell source for temporomandibular joint tissue engineering. Costal cartilage is commonly harvested for various types of facial reconstructive surgery. The ability of costal chondrocytes (CCs) to produce relevant extracellular matrix, including glycosaminoglycans (GAGs) and collagens, makes them an appealin...

Sabitha, N.; Rao, K.P.; Rao, C.P.; Rao, M.S., 2007: Genetic variation, heritability and genetic advance for yield components in sugarcane. Sugar Tech 9(4): 290-292

Moses, A.; Gabrilove, J.L., 1958: Salt losing nephropathy. Journal of the Mount Sinai Hospital, New York 25(5): 450-454

Baird, R.L., 1932: A study of the large Banana Spider. Ohio Journal of Science, Vol. 32(No. 4: 321-322

Gordon A.J.; Griffith P.R., 1973: Chemical and in vivo evaluation of a brown midrib mutant of zea mays part 2 nmr spectra of digested and undigested alkali lignins and undigested di methyl formamide lignins. Journal of the Science of Food & Agriculture 24(5): 579-587

Petersen, Hw, 1974: Insulating farmhouses. Landbo nyt: 28 (11) 626-627

Hill, T.; Vasudevan, R., 2001: Loosening the ties. Interview by Maura Thompson. Health Service Journal 110(5713): 34-35