+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Bile carcinoembryonic antigen levels and occult hepatic metastases from colorectal cancer

, : Bile carcinoembryonic antigen levels and occult hepatic metastases from colorectal cancer. Diseases of the Colon and Rectum 43(9): 1292-5; Discussion 1295-6

Up to 30 percent of patients will have occult hepatic metastases at the time of curative surgery for colorectal cancer. The ability to predict this group of patients would allow better targeting of appropriate therapy. It has been shown previously that patients with overt hepatic metastases have significantly high levels of carcinoembryonic antigen in gallbladder bile compared with serum levels. The aim of this study was to assess the accuracy of bile carcinoembryonic antigen levels taken at the time of operation in predicting patients with occult hepatic metastases. Bile and serum carcinoembryonic antigen samples were collected from 37 patients undergoing surgery for colorectal cancer, 26 of whose procedures were deemed curative and who were followed up for a median of 63.5 months. Twelve patients were alive with no evidence of recurrent disease, and two had recurrent disease, whereas 12 died of disease. The median (interquartile range) serum carcinoembryonic antigen in the disease-free group was 2.8 (1.1-6.1) ng/ml, and in the recurrent group it was 6.35 (4.3-30) ng/ml (P = 0.006), whereas bile carcinoembryonic antigen in the disease-free group was 7 (5-39) ng/ml as compared with 31 (5-383.7) ng/ml in the recurrent group (P = 0.210). The accuracy of serum carcinoembryonic antigen in predicting occult hepatic metastases was 77 percent compared with 72 percent for bile carcinoembryonic antigen. Intraoperative bile carcinoembryonic antigen levels are no more accurate than serum carcinoembryonic antigen levels in predicting occult hepatic metastases in patients undergoing potentially curative colorectal cancer surgery.


PMID: 11005500

Other references

Jakobsen, B.M.; Ottosen, P., 1968: Aorto-femoral transplantation. Ugeskrift for Laeger 130(51): 2228-2232

Yeh, T-Lin.; Huang, F-Yuan.; Shyur, S-Dar.; Chen, T-Ling.; Lee, C-Shen.; Huang, D.Tsung-Ning., 2011: Juvenile idiopathic arthritis presenting with prolonged fever. Systemic-onset juvenile idiopathic arthritis (s-JIA) is a systemic disease often accompanied by a fever. We examined 16 patients with s-JIA and reported the clinical manifestations, laboratory data, treatments and outcomes. From 1984 to 2007, 16 c...

Simples, J.E.Jr.; Meriney, S.D., 1997: Cytoplasmic messengers regulate action potential burst-induced relief of G protein-mediated inhibition of N-type Ca-2+ current in parasympathetic neurons. Society for Neuroscience Abstracts 23(1-2): 857

Zubkus, Lp, 1977: Results and ways of introducing ornamental plants into the Central Siberian Botanical Garden. Dekorativnye rasteniia i ikh introduktsiia v Zapadnuiu Sibir': -43

Bahmanyar, M., 1979: Benefit versus risk factors in prophylactic vaccination against rabies. A reliable evaluation of the universally adopted post-exposure prophylactic treatment against rabies, initiated by Louis Pasteur, became feasible only sixty years after its world-wide application. Accumulated observations and data during that peri...

Rix, E.F.; Barclay, L.; Wilson, S., 2015: Can a white nurse get it? 'Reflexive practice' and the non-Indigenous clinician/researcher working with Aboriginal people. Reflexivity is crucial for non-Aboriginal researchers working with Aboriginal people. This article describes a process of 'reflexive practice' undertaken by a white clinician/researcher while working with Aboriginal people. The clinician...

Arroyuelo, A.; Vila, J.A.; Martin, O.A., 2016: Azahar: a PyMOL plugin for construction, visualization and analysis of glycan molecules. Glycans are key molecules in many physiological and pathological processes. As with other molecules, like proteins, visualization of the 3D structures of glycans adds valuable information for understanding their biological function. Hence, here we...

Laskowski, K.L.; Wolf, M.; Bierbach, D., 2016: The making of winners (and losers): how early dominance interactions determine adult social structure in a clonal fish. Across a wide range of animal taxa, winners of previous fights are more likely to keep winning future contests, just as losers are more likely to keep losing. At present, such winner and loser effects are considered to be fairly transient. However...

Anonymous, 1981: Medicare Program; statistical standards for evaluating intermediary performance during fiscal year 1981--Health Care Financing Administration. General notice with comment period. Federal Register 46(135): 36749-36753

Felitsyn Sergei; Sturesson Ulf; Popov Leonid; Holmer Lars, 1998: Nd isotope composition and rare earth element distribution in early Paleozoic biogenic apatite from Baltoscandia; a signature of Iapetus ocean water. Analyses of the Nd isotopic composition and REE distribution in biogenic apatite (organophosphatic brachiopods and conodont elements) from the Cambrian and Ordovician sequences of the Baltic plate give new insights into the development of the sout...